Sudden cardiac death and the role of medical therapy

被引:31
作者
Arshad, Aysha [1 ]
Mandava, Anisha [1 ]
Kamath, Ganesh [1 ]
Musat, Dan [1 ]
机构
[1] St Lukes Roosevelt Hosp, Div Cardiol, New York, NY 10025 USA
关键词
D O I
10.1016/j.pcad.2007.12.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sudden cardiac death (SCD) accounts for more than 300,000 deaths annually in the United States. The goal of medical therapy in patients considered to be at high risk (coronary artery disease, post myocardial infarction, structural heart disease and congestive heart failure) involves treating the disease state as well prevention of potentially lethal arrhythmias. Treatment with angiotensin receptor inhibitors, beta blockers and statins has been shown to improve survival in this high risk group. The use of anti-arrhythmic drugs has been studied and found to lack efficacy and has potential for adverse effects. The role of omega-3 fatty acids in preventing sudden death continues to evolve. © 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:420 / 438
页数:19
相关论文
共 146 条
[71]   DIABETIC-PATIENTS AND BETA-BLOCKERS AFTER ACUTE MYOCARDIAL-INFARCTION [J].
KJEKSHUS, J ;
GILPIN, E ;
CALI, G ;
BLACKEY, AR ;
HENNING, H ;
ROSS, J .
EUROPEAN HEART JOURNAL, 1990, 11 (01) :43-50
[72]   Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice - Evidence for antiinflammatory effects of rosuvastatin [J].
Kleemann, R ;
Princen, HMG ;
Emeis, JJ ;
Jukema, JW ;
Fontijn, RD ;
Horrevoets, AJG ;
Kooistra, T ;
Havekes, LM .
CIRCULATION, 2003, 108 (11) :1368-1374
[73]   A CLINICAL-TRIAL OF THE ANGIOTENSIN-CONVERTING-ENZYME INHIBITOR TRANDOLAPRIL IN PATIENTS WITH LEFT-VENTRICULAR DYSFUNCTION AFTER MYOCARDIAL-INFARCTION [J].
KOBER, L ;
TORPPEDERSEN, C ;
CARLSEN, JE ;
BAGGER, H ;
ELIASEN, P ;
LYNGBORG, K ;
VIDEBEK, J ;
COLE, DS ;
AUCLERT, L ;
PAULY, NC ;
ALIOT, E ;
PERSSON, S ;
CAMM, AJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (25) :1670-1676
[74]   Early β-blocker therapy for acute myocardial infarction in elderly patients [J].
Krumholz, HM ;
Radford, MJ ;
Wang, Y ;
Chen, J ;
Marciniak, TA .
ANNALS OF INTERNAL MEDICINE, 1999, 131 (09) :648-+
[75]   Membrane effects of the n-3 fish oil fatty acids, which prevent fatal ventricular arrhythmias [J].
Leaf, A ;
Xiao, YF ;
Kang, JX ;
Billman, GE .
JOURNAL OF MEMBRANE BIOLOGY, 2005, 206 (02) :129-139
[76]   The electrophysiologic basis for the antiarrhythmic and anticonvulsant effects of n-3 polyunsaturated fatty acids: Heart and brain [J].
Leaf, A .
LIPIDS, 2001, 36 :S107-S110
[77]   Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake [J].
Leaf, A ;
Albert, CM ;
Josephson, M ;
Steinhaus, D ;
Kluger, J ;
Kang, JX ;
Cox, B ;
Zhang, H ;
Schoenfeld, D .
CIRCULATION, 2005, 112 (18) :2762-2768
[78]   The electrophysiological basis for the antiarrhythmic actions of polyunsaturated fatty acids [J].
Leaf, A .
EUROPEAN HEART JOURNAL SUPPLEMENTS, 2001, 3 (0D) :D98-D105
[79]   Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids [J].
Leaf, Alexander .
FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2006, 20 (06) :525-538
[80]   Omega-3 fatty acids and prevention of arrhythmias [J].
Leaf, Alexander .
CURRENT OPINION IN LIPIDOLOGY, 2007, 18 (01) :31-34