RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

被引：432

作者：

Kampers, T ^{[1
]}

Friedhoff, P ^{[1
]}

Biernat, J ^{[1
]}

Mandelkow, EM ^{[1
]}

机构：

[1] DESY,MAX PLANCK UNIT STRUCT MOL BIOL,D-22607 HAMBURG,GERMANY

来源：

FEBS LETTERS | 1996年 / 399卷 / 03期

关键词：

paired helical filament; Alzheimer's disease; microtubule-associated protein; RNA;

D O I：

10.1016/S0014-5793(96)01386-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The microtubule-associated protein tau is the main component of the paired helical filaments (PHFs) of Alzheimer's disease, the most common senile dementia, To understand the origin of tau's abnormal assembly me have studied the influence of other cytosolic components, Here me report that PHF assembly is strongly enhanced by RNA. The RNA-induced assembly of PHFs is dependent on the formation of intermolecular disulfide bridges involving Cys(322) in the third repeat of tau, and it includes the dimerization of tau as an early intermediate, Three-repeat constructs polymerize most efficiently, two repeat constructs are the minimum number required for assembly, and even all six full-length isoforms of tau can be induced to form PHFs by RNA.

引用

页码：344 / 349

页数：6

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