Islet transplantation: Present clinical situation and future aspects

被引：20

作者：

Bretzel, RG

Brendel, M

Eckhard, M

Brandhorst, D

Jaeger, C

Hatziagelaki, E

Federlin, K

机构：

[1] Univ Giessen, Dept Med 3, Giessen, Germany

[2] Univ Giessen, Policlin, Giessen, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2001年 / 109卷

关键词：

islet transplantation; kidney transplantation; end-stage renal disease; alloimmunity; autoimmunity; immunosuppression; immunotolerance; gene therapy;

D O I：

10.1055/s-2001-18597

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Beta-cell replacement either by pancreatic organ or islet cell transplantation is the only treatment to achieve an insulin-independent, normoglycemic state and to avoid hypoglycemic episodes in patients with type 1 diabetes mellitus, This article will review the state-of-the-art in clinical islet cell personal experience. transplantation at the dawn of the new millenium and will provide an outlook on the basis of extended personal experience.

引用

收藏

页码：S384 / S399

页数：16

相关论文

共 65 条

[1] Long-term function (6 years) of islet allografts in type 1 diabetes [J].

Alejandro, R ;

Lehmann, R ;

Ricordi, C ;

Kenyon, NS ;

Angelico, MC ;

Burke, G ;

Esquenazi, V ;

Nery, J ;

Betancourt, AE ;

Kong, SS ;

Miller, J ;

Mintz, DH .

DIABETES, 1997, 46 (12) :1983-1989

[2] Prevention of autoimmune islet allograft destruction by engraftment of donor T cells [J].

Bartlett, ST ;

Schweitzer, EJ ;

Kuo, PC ;

Johnson, LB ;

Delatorre, A ;

Hadley, GA .

TRANSPLANTATION, 1997, 63 (02) :299-303

[3] Sustained proliferation of PDX-1+ cells derived from human islets [J].

Beattie, GM ;

Itkin-Ansari, P ;

Cirulli, V ;

Leibowitz, G ;

Lopez, AD ;

Bossie, S ;

Mally, MI ;

Levine, F ;

Hayek, A .

DIABETES, 1999, 48 (05) :1013-1019

[4] Incompatibility between human blood and isolated islets of Langerhans - A finding with implications for clinical intraportal islet transplantation? [J].

Bennet, W ;

Sundberg, B ;

Groth, CG ;

Brendel, MD ;

Brandhorst, D ;

Brandhorst, H ;

Bretzel, RG ;

Elgue, G ;

Larsson, R ;

Nilsson, B ;

Korsgren, O .

DIABETES, 1999, 48 (10) :1907-1914

[5] Modulation of humoral islet autoimmunity by pancreas allotransplantation influences allograft outcome in patients with type 1 diabetes [J].

Braghi, S ;

Bonifacio, E ;

Secchi, A ;

Di Carlo, V ;

Pozza, G ;

Bosi, E .

DIABETES, 2000, 49 (02) :218-224

[6] Islet isolation from the pancreas of large mammals and humans: 10 years of experience [J].

Brandhorst, D ;

Brandhorst, H ;

Hering, BJ ;

Federlin, K ;

Bretzel, RG .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 1995, 103 :3-14

[7]

BRANDHORST D, 1994, TRANSPLANT P, V26, P592

[8]

BRANDHORST D, 1994, TRANSPLANT P, V26, P3529

[9]

Brandhorst D, 1995, TRANSPLANT P, V27, P3337

[10] Large variability of the intracellular ATP content of human islets isolated from different donors [J].

Brandhorst, D ;

Brandhorst, H ;

Hering, BJ ;

Federlin, K ;

Bretzel, RG .

JOURNAL OF MOLECULAR MEDICINE-JMM, 1999, 77 (01) :93-95

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