The Molecular Architecture of HIV

被引：131

作者：

Briggs, John A. G. ^{[1
]}

Kraeusslich, Hans-Georg ^{[2
]}

机构：

[1] European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany

[2] Heidelberg Univ, Dept Infect Dis, D-69120 Heidelberg, Germany

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2011年 / 410卷 / 04期

关键词：

human immunodeficiency virus; assembly; maturation; Gag; capsid; HUMAN-IMMUNODEFICIENCY-VIRUS; VITRO ASSEMBLY PROPERTIES; TYPE-1 CAPSID PROTEIN; IN-VITRO; GAG PROTEIN; ELECTRON CRYOTOMOGRAPHY; NUCLEOCAPSID PROTEINS; PARTICLE-PRODUCTION; CLEAVAGE SITES; MATRIX PROTEIN;

D O I：

10.1016/j.jmb.2011.04.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Assembly of human immunodeficiency virus type 1 is driven by oligomerization of the Gag polyprotein at the plasma membrane of an infected cell, leading to membrane envelopment and budding of an immature virus particle. Proteolytic cleavage of Gag at five positions subsequently causes a dramatic rearrangement of the interior virion organization to form an infectious particle. Within the mature virus, the genome is encased within a conical capsid core. Here, we describe the molecular architecture of the virus assembly site, the immature virus, the maturation intermediates and the mature virus core and highlight recent advances in our understanding of these processes from electron microscopy and X-ray crystallography studies. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：491 / 500

页数：10

共 57 条

[11] In vitro assembly properties of human immunodeficiency virus type 1 Gag protein lacking the p6 domain [J].

Campbell, S ;

Rein, A .

JOURNAL OF VIROLOGY, 1999, 73 (03) :2270-2279

[12] Cryo Electron Tomography of Native HIV-1 Budding Sites [J].

Carlson, Lars-Anders ;

de Marco, Alex ;

Oberwinkler, Heike ;

Habermann, Anja ;

Briggs, John A. G. ;

Kraeusslich, Hans-Georg ;

Gruenewald, Kay .

PLOS PATHOGENS, 2010, 6 (11)

[13] Three-Dimensional Analysis of Budding Sites and Released Virus Suggests a Revised Model for HIV-1 Morphogenesis [J].

Carlson, Lars-Anders ;

Briggs, John A. G. ;

Glass, Baerbel ;

Riches, James D. ;

Simon, Martha N. ;

Johnson, Marc C. ;

Mueller, Barbara ;

Gruenewald, Kay ;

Kraeusslich, Hans-Georg .

CELL HOST & MICROBE, 2008, 4 (06) :592-599

[14] Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus [J].

Chertova, E ;

Bess, JW ;

Crise, BJ ;

Sowder, RC ;

Schaden, TM ;

Hilburn, JM ;

Hoxie, JA ;

Benveniste, RE ;

Lifson, JD ;

Henderson, LE ;

Arthur, LO .

JOURNAL OF VIROLOGY, 2002, 76 (11) :5315-5325

[15] Basic residues in human immunodeficiency virus type 1 nucleocapsid promote virion assembly via interaction with RNA [J].

Cimarelli, A ;

Sandin, S ;

Höglund, S ;

Luban, J .

JOURNAL OF VIROLOGY, 2000, 74 (07) :3046-3057

[16] Mutational analysis of the C-terminal Gag cleavage sites in human immunodeficiency virus type 1 [J].

Coren, Lori V. ;

Thomas, James A. ;

Chertova, Elena ;

Sowder, Raymond C., II ;

Gagliardi, Tracy D. ;

Gorelick, Robert J. ;

Ott, David E. .

JOURNAL OF VIROLOGY, 2007, 81 (18) :10047-10054

[17] Structural Analysis of HIV-1 Maturation Using Cryo-Electron Tomography [J].

de Marco, Alex ;

Mueller, Barbara ;

Glass, Baerbel ;

Riches, James D. ;

Kraeusslich, Hans-Georg ;

Briggs, John A. G. .

PLOS PATHOGENS, 2010, 6 (11)

[18] Conserved and Variable Features of Gag Structure and Arrangement in Immature Retrovirus Particles [J].

de Marco, Alex ;

Davey, Norman E. ;

Ulbrich, Pavel ;

Phillips, Judith M. ;

Lux, Vanda ;

Riches, James D. ;

Fuzik, Tibor ;

Ruml, Tomas ;

Kraeusslich, Hans-Georg ;

Vogt, Volker M. ;

Briggs, John A. G. .

JOURNAL OF VIROLOGY, 2010, 84 (22) :11729-11736

[19] FUNCTIONAL DOMAINS OF THE CAPSID PROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].

DORFMAN, T ;

BUKOVSKY, A ;

OHAGEN, A ;

HOGLUND, S ;

GOTTLINGER, HG .

JOURNAL OF VIROLOGY, 1994, 68 (12) :8180-8187

[20] ASSEMBLY OF RECOMBINANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 CAPSID PROTEIN INVITRO [J].

EHRLICH, LS ;

AGRESTA, BE ;

CARTER, CA .

JOURNAL OF VIROLOGY, 1992, 66 (08) :4874-4883

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