Maintaining Tissue Homeostasis: Dynamic Control of Somatic Stem Cell Activity

被引：276

作者：

Biteau, Benoit ^{[1
]}

Hochmuth, Christine E. ^{[1
]}

Jasper, Heinrich ^{[1
]}

机构：

[1] Univ Rochester, Dept Biol, Rochester, NY 14627 USA

来源：

CELL STEM CELL | 2011年 / 9卷 / 05期

关键词：

CONTROLS SELF-RENEWAL; INTESTINAL REGENERATION; BACTERIAL-INFECTION; DROSOPHILA MIDGUT; PROGENITOR CELLS; DUAL OXIDASE; NOTCH; PROLIFERATION; PATHWAY; DIFFERENTIATION;

D O I：

10.1016/j.stem.2011.10.004

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Long-term maintenance of tissue homeostasis relies on the accurate regulation of somatic stem cell activity. Somatic stem cells have to respond to tissue damage and proliferate according to tissue requirements while avoiding overproliferation. The regulatory mechanisms involved in these responses are now being unraveled in the intestinal epithelium of Drosophila, providing new insight into strategies and mechanisms of stem cell regulation in barrier epithelia. Here, we review these studies and highlight recent findings in vertebrate epithelia that indicate significant conservation of regenerative strategies between vertebrate and fly epithelia.

引用

收藏

页码：402 / 411

页数：10

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