High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis

被引：70

作者：

Ahn, Jiyun ^{[1
]}

Lee, Hyunjung ^{[1
]}

Chung, Chang Hwa ^{[1
]}

Ha, Taeyoul ^{[1
]}

机构：

[1] Korea Food Res Inst, Res Div Emerging Innovat Technol, Funct Food Res Ctr, Seoungnam Si 463746, Gyeonggi Do, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 414卷 / 04期

关键词：

Non-alcoholic fatty liver disease; Steatosis; MicroRNA-467b; Lipoprotein lipase; Insulin resistance; LIVER-DISEASE; INSULIN-RESISTANCE; INTRAABDOMINAL FAT; CHOLINE-DEFICIENT; INDUCED OBESITY; ADIPOSE-TISSUE; MICE; EXPRESSION; ASSOCIATION; METABOLISM;

D O I：

10.1016/j.bbrc.2011.09.120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation and is presently the most common chronic liver disease. However, the mechanisms underlying the development of steatosis remain unclear. MicroRNAs (miRNAs) are small non-coding RNAs that modulate a variety of biological functions. We have investigated the role of miRNA in the development of steatosis. We found that miR-467b expression is significantly downregulated in liver tissues of high-fat diet fed mice and in steatosis-induced hepatocytes. The downregulation of miR-467b resulted in the upregulation of hepatic lipoprotein lipase (LPL), the direct target of miR-467b. Moreover, the interaction between miR-467b and LPL was associated with insulin resistance, a major cause of NAFLD. These results suggest that downregulation of miR-467b is involved in the development of hepatic steatosis by modulating the expression of its target, LPL. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：664 / 669

页数：6