Lost to translation: when autophagy targets mature ribosomes

被引：47

作者：

Beau, Isabelle ^{[1
,2
]}

Esclatine, Audrey ^{[1
,2
]}

Codogno, Patrice ^{[1
,2
]}

机构：

[1] INSERM, U756, F-92290 Chatenay Malabry, France

[2] Univ Paris 11, Fac Pharm, F-92290 Chatenay Malabry, France

来源：

TRENDS IN CELL BIOLOGY | 2008年 / 18卷 / 07期

关键词：

D O I：

10.1016/j.tcb.2008.05.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy and the ubiquitin proteasome system (UPS) mediate the degradation of cellular proteins. However, we are now realizing that autophagy can also be a selective process that degrades various organelles. Peter and co-workers discovered a selective autophagic pathway that targets ribosomes in Saccharomyces cerevisiae. This pathway, which they termed ribophagy, depends on Ubp3 ubiquitin protease and its partner Bre5. This is an important finding, because it suggests that the number of ribosomes can be adjusted to match the needs of the cell.

引用

页码：311 / 314

页数：4

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