Mice without telomerase: what can they teach us about human cancer?

被引：104

作者：

Artandi, SE ^{[1
]}

DePinho, RA

机构：

[1] Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 08期

关键词：

D O I：

10.1038/78595

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Unicellular organisms, human cells and mice have provided insights into how the processes of senescence, crisis, genomic instability and cancer in humans. Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic Instability due to telomere dysfunction, and the suppression or promotion of cancer.

引用

页码：852 / 855

页数：4

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