Engineered cellular response to scaffold architecture in a rabbit trephine defect

被引:70
作者
Simon, JL
Roy, TD
Parsons, JR [1 ]
Rekow, ED
Thompson, VP
Kemnitzer, J
Ricci, JL
机构
[1] Univ Med & Dent New Jersey, Dept Orthopaed, Newark, NJ 07103 USA
[2] Rutgers State Univ, Dept Biochem Engn, New Brunswick, NJ 08903 USA
[3] Integra Lifsci Inc, Plainsboro, NJ 08536 USA
关键词
scaffold architecture; porous scaffold; poly(DTE carbonate); solid freeform fabrication; 3-D printing;
D O I
10.1002/jbm.a.10569
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Tight control of pore architecture in porous scaffolds for bone repair is critical for a fully elucidated tissue response. Solid freeform fabrication (SFF) enables construction of scaffolds with tightly controlled pore architecture. Four types of porous scaffolds were constructed using SFF and evaluated in an 8-mm rabbit trephine defect at 8 and 16 weeks (n = 6): a lacticle/glycolide (50:50) copolymer scaffold with 20% w/w tri-calcium phosphate and random porous architecture (Group 1); another identical design made from poly(desaminotyrosyl-tyrosine ethyl ester carbonate) [poly(DTE carbonate)], a tyrosine-derived pseudo-polyamino acid (Group 2); and two poly(DTE carbonate) scaffolds containing 500 mum pores separated by 500-mum thick walls, one type with solid walls (Group 3), and one type with microporous walls (Group 4). A commercially available coralline scaffold (Interpore) with a 486-mum average pore size and empty defects were used as controls. There was no significant difference in the overall amount of bone ingrowth in any of the devices, as found by radiographic analysis, but patterns of bone formation matched the morphology of the scaffold. These results suggest that controlled scaffold architecture can be superimposed on biomaterial composition to design and construct scaffolds with improved fill time. (C) 2003 Wiley Periodicals, Inc.
引用
收藏
页码:275 / 282
页数:8
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