DNA nanodevices

被引:194
作者
Simmel, FC
Dittmer, WU
机构
[1] Univ Munich, Dept Phys, D-80539 Munich, Germany
[2] Univ Munich, Ctr Nanosci, D-80539 Munich, Germany
关键词
DNA; molecular machines; molecular recognition; nanobiotechnology; nanodevices;
D O I
10.1002/smll.200400111
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The molecular recognition properties of DNA molecules combined with the distinct mechanical properties of single and double strands of DNA can be utilized for the construction of nanodevices, which can perform ever more tasks with possible applications ranging from nanoconstruction to intelligent drug delivery. With the help of DNA it is possible to construct machinelike devices that are capable of rotational motion, pulling and stretching, or even unidirectional motion. It is possible to devise autonomous nanodevices, to grab and release molecules, and also to perform simple information-processing tasks.
引用
收藏
页码:284 / 299
页数:16
相关论文
共 155 条
[1]   Stochastic computing with biomolecular automata [J].
Adar, R ;
Benenson, Y ;
Linshiz, G ;
Rosner, A ;
Tishby, N ;
Shapiro, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (27) :9960-9965
[2]   MOLECULAR COMPUTATION OF SOLUTIONS TO COMBINATORIAL PROBLEMS [J].
ADLEMAN, LM .
SCIENCE, 1994, 266 (5187) :1021-1024
[3]   DNA duplex-quadruplex exchange as the basis for a nanomolecular machine [J].
Alberti, P ;
Mergny, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1569-1573
[4]  
Alberts B., 1994, MOL BIOL CELL
[5]   Organization of 'nanocrystal molecules' using DNA [J].
Alivisatos, AP ;
Johnsson, KP ;
Peng, XG ;
Wilson, TE ;
Loweth, CJ ;
Bruchez, MP ;
Schultz, PG .
NATURE, 1996, 382 (6592) :609-611
[6]  
[Anonymous], 2001, MECH MOTOR PROTEINS
[7]   COMPUTATIONAL FUNCTIONS IN BIOCHEMICAL REACTION NETWORKS [J].
ARKIN, A ;
ROSS, J .
BIOPHYSICAL JOURNAL, 1994, 67 (02) :560-578
[8]   Stretch genes [J].
Austin, RH ;
Brody, JP ;
Cox, EC ;
Duke, T ;
Volkmuth, W .
PHYSICS TODAY, 1997, 50 (02) :32-38
[9]   ISOLATION OF NEW RIBOZYMES FROM A LARGE POOL OF RANDOM SEQUENCES [J].
BARTEL, DP ;
SZOSTAK, JW .
SCIENCE, 1993, 261 (5127) :1411-1418
[10]   DNA molecule provides a computing machine with both data and fuel [J].
Benenson, Y ;
Adar, R ;
Paz-Elizur, T ;
Livneh, Z ;
Shapiro, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2191-2196