DNA nanodevices

被引:194
作者
Simmel, FC
Dittmer, WU
机构
[1] Univ Munich, Dept Phys, D-80539 Munich, Germany
[2] Univ Munich, Ctr Nanosci, D-80539 Munich, Germany
关键词
DNA; molecular machines; molecular recognition; nanobiotechnology; nanodevices;
D O I
10.1002/smll.200400111
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The molecular recognition properties of DNA molecules combined with the distinct mechanical properties of single and double strands of DNA can be utilized for the construction of nanodevices, which can perform ever more tasks with possible applications ranging from nanoconstruction to intelligent drug delivery. With the help of DNA it is possible to construct machinelike devices that are capable of rotational motion, pulling and stretching, or even unidirectional motion. It is possible to devise autonomous nanodevices, to grab and release molecules, and also to perform simple information-processing tasks.
引用
收藏
页码:284 / 299
页数:16
相关论文
共 155 条
[61]   FORCE OF SINGLE KINESIN MOLECULES MEASURED WITH OPTICAL TWEEZERS [J].
KUO, SC ;
SHEETZ, MP .
SCIENCE, 1993, 260 (5105) :232-234
[62]   Construction, analysis, ligation, and self-assembly of DNA triple crossover complexes [J].
LaBean, TH ;
Yan, H ;
Kopatsch, J ;
Liu, FR ;
Winfree, E ;
Reif, JH ;
Seeman, NC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (09) :1848-1860
[63]  
Lakowicz J.R., 2004, PRINCIPLES FLUORESCE, V3rd
[64]   INTRAMOLECULAR FOLDING OF A FRAGMENT OF THE CYTOSINE-RICH STRAND OF TELOMERIC DNA INTO AN I-MOTIF [J].
LEROY, JL ;
GUERON, M ;
MERGNY, JL ;
HELENE, C .
NUCLEIC ACIDS RESEARCH, 1994, 22 (09) :1600-1606
[65]   ACID MULTIMERS OF OLIGODEOXYCYTIDINE STRANDS - STOICHIOMETRY, BASE-PAIR CHARACTERIZATION, AND PROTON-EXCHANGE PROPERTIES [J].
LEROY, JL ;
GEHRING, K ;
KETTANI, A ;
GUERON, M .
BIOCHEMISTRY, 1993, 32 (23) :6019-6031
[66]   In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme [J].
Li, J ;
Zheng, WC ;
Kwon, AH ;
Lu, Y .
NUCLEIC ACIDS RESEARCH, 2000, 28 (02) :481-488
[67]  
Li JWJ, 2002, NANO LETT, V2, P315, DOI [10.1021/nl015713+, 10.1021/n1015713+]
[68]  
Li X., 2004, ANGEW CHEM, V116, P4956
[69]   DNA-Templated organic synthesis: Nature's strategy for controlling chemical reactivity applied to synthetic molecules [J].
Li, XY ;
Liu, DR .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (37) :4848-4870
[70]   DNA SOLUTION OF HARD COMPUTATIONAL PROBLEMS [J].
LIPTON, RJ .
SCIENCE, 1995, 268 (5210) :542-545