Oxidative stress in alzheimer's disease: A review on emergent natural polyphenolic therapeutics

被引：204

作者：

Cassidy, Luke ^{[1
]}

Fernandez, Francesca ^{[1
]}

Johnson, Joel B. ^{[2
]}

Naiker, Mani ^{[2
]}

Owoola, Akeem G. ^{[3
,4
]}

Broszczak, Daniel A. ^{[3
,4
]}

机构：

[1] Australian Catholic Univ, Fac Heath Sci, Sch Behav & Hlth Sci, 1100 Nudgee Rd, Banyo, Qld 4014, Australia

[2] Cent Queensland Univ, Sch Hlth Med & Appl Sci, 630 Ibis Ave, North Rockhampton, Qld 4701, Australia

[3] Queensland Univ Technol, Fac Hlth, Sch Biomed Sci, 2 George St, Brisbane, Qld 4000, Australia

[4] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Tissue Repair & Translat Physiol Program, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia

来源：

COMPLEMENTARY THERAPIES IN MEDICINE | 2020年 / 49卷

关键词：

AMYLOID-BETA-PEPTIDE; ADVANCED GLYCATION ENDPRODUCTS; TAU-PHOSPHORYLATION; LIPID-PEROXIDATION; VITAMIN-E; MITOCHONDRIAL DYSFUNCTION; HYPERPHOSPHORYLATED TAU; COGNITIVE IMPAIRMENT; SYNAPTIC DYSFUNCTION; ANTIOXIDANT ACTIVITY;

D O I：

10.1016/j.ctim.2019.102294

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Objectives: The aim of this research was to review the literature on Alzheimer's disease (AD) with a focus on polyphenolics as antioxidant therapeutics. Design: This review included a search of the literature up to and including September 2019 in PubMed and MEDLINE databases using search terms that included: Alzheimer's Disease, A beta peptide, tau, oxidative stress, redox, oxidation, therapeutic, antioxidant, natural therapy, polyphenol. Any review articles, case studies, research reports and articles in English were identified and subsequently interrogated. Citations within relevant articles were also examined for consideration in this review. Results: Alzheimer's disease is a neurodegenerative disorder that is clinically characterised by the progressive deterioration of cognitive functions and drastic changes in behaviour and personality. Due to the significant presence of oxidative damage associated with abnormal A beta accumulation and neurofibrillary tangle deposition in AD patients' brains, antioxidant drug therapy has been investigated as potential AD treatment. In particular, naturally occurring compounds, such as plant polyphenols, have been suggested to have potential neuroprotective effects against AD due to their diverse array of physiological actions, which includes potent antioxidant effects. Conclusions: The impact of oxidative stress and various mechanisms of pathogenesis in AD pathophysiology was demonstrated along with the therapeutic potential of emergent antioxidant drugs to address such mechanism of oxidation.

引用

页数：11

共 184 条

[1]

Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease [J].