Gastroprotective effect of leptin on gastric mucosal injury induced by ischemia-reperfusion is related to gastric histamine content in rats

被引：20

作者：

Erkasap, N ^{[1
]}

Uzuner, K

Serteser, M

Köken, T

Aydin, Y

机构：

[1] Osmangazi Univ, Fac Med, Dept Physiol, Eskisehir, Turkey

[2] Afyon Kocatepe Univ, Fac Med, Dept Biochem, Afyon, Turkey

来源：

PEPTIDES | 2003年 / 24卷 / 08期

关键词：

gastric ischemia-reperfusion; leptin; histamine;

D O I：

10.1016/j.peptides.2003.06.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leptin has cytoprotective effect to gastric mucosal injury in rats. We aimed to test the hypothesis that leptin induced histamine is involved in the prevention of ischemia-reperfusion (I/R) induced gastric mucosal injury in rats. At the end of the 30 min celiac artery occlusion and 12 h reperfusion process, serum and gastric tissue samples were taken from three group of rats to measure oxidative status, histamine levels and for histological examinations. Leptin decreased ulcer and polymorphonuclear leukocyte (PMNL) index, and serum malondialdehyde (MDA) and protein carbonyl content but increased gastric tissue histamine levels. We concluded that leptin exerts a protective effect on gastric mucosa to I/R induced gastric injury probably through increasing tissue histamine content which, in turn, maintain the gastric mucosal blood flow. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1181 / 1187

页数：7

共 26 条

[1] PROTECTION AGAINST GASTRIC ISCHEMIA-REPERFUSION INJURY BY NITRIC-OXIDE GENERATORS [J].

ANDREWS, FJ ;

MALCONTENTIWILSON, C ;

OBRIEN, PE .

DIGESTIVE DISEASES AND SCIENCES, 1994, 39 (02) :366-373

[2] AN UPDATE ON HISTAMINE H-3 RECEPTORS AND GASTROINTESTINAL FUNCTIONS [J].

BERTACCINI, G ;

CORUZZI, G .

DIGESTIVE DISEASES AND SCIENCES, 1995, 40 (09) :2052-2063

[3] Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions [J].

Brzozowski, T ;

Konturek, PC ;

Konturek, SJ ;

Sliwowski, Z ;

Drozdowicz, D ;

Stachura, J ;

Pajdo, R ;

Hahn, EG .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 385 (01) :47-61

[4] Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia-reperfusion into gastric ulcers [J].

Brzozowski, T ;

Konturek, PC ;

Konturek, SJ ;

Drozdowicz, D ;

Kwiecien, S ;

Pajdo, R ;

Bielanski, W ;

Hahn, EG .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 398 (01) :147-158

[5] Starvation, leptin and epithelial cell proliferation in the gastrointestinal tract of the mouse [J].

Chaudhary, M ;

Mandir, N ;

FitzGerald, AJ ;

Howard, JK ;

Lord, GM ;

Ghatei, MA ;

Bloom, SR ;

Goodlad, RA .

DIGESTION, 2000, 61 (04) :223-229

[6] Gastric mucosal injury induced by local ischemia-reperfusion in rats - Role of endogenous endothelin-1 and free radical [J].

Hassan, M ;

Kashimura, H ;

Matsumaru, K ;

Nakahara, A ;

Iwata, R ;

Hayashi, T ;

Muto, H ;

Tanaka, N ;

Goto, K ;

Fukutomi, H .

DIGESTIVE DISEASES AND SCIENCES, 1997, 42 (07) :1375-1380

[7] Distinct effects of tetragastrin, histamine, and CCh on rat gastric mucin synthesis and contribution of NO [J].

Ichikawa, T ;

Ishihara, K ;

Kusakabe, T ;

Kurihara, M ;

Kawakami, T ;

Takenaka, T ;

Saigenji, K ;

Hotta, K .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 274 (01) :G138-G146

[8] Effects of cimetidine on acute gastric mucosal injury induced by ischemia-reperfusion in rats [J].

Kitano, M ;

Wada, K ;

Kamisaki, Y ;

Nakamoto, K ;

Kishimoto, Y ;

Kawasaki, H ;

Itoh, T .

PHARMACOLOGY, 1997, 55 (03) :154-164

[9]

KIUCHI Y, 1998, GEN PHARMACOL, V2, P271

[10] Role of leptin in ulcer healing [J].

Konturek, PC ;

Brzozowski, T ;

Sulekova, Z ;

Brzozowska, I ;

Duda, A ;

Meixner, H ;

Hahn, EG ;

Konturek, SJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 414 (01) :87-97

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