Efficient and selective Pt/C-catalyzed H-D exchange reaction of aromatic rings

被引：66

作者：

Ito, Nobuhiro ^{[2
]}

Esaki, Hiroyoshi ^{[1
]}

Maesawa, Tsuneaki ^{[2
]}

Imamiya, Eikoh ^{[2
]}

Maegawa, Tomohiro ^{[1
]}

Sajiki, Hironao ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Labs Med Chem, Gifu 5028585, Japan

[2] Wako Pure Chem Ind Ltd, Chem Prod Res Labs, Kawagoe, Saitama 3501101, Japan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2008年 / 81卷 / 02期

关键词：

HYDROGEN ISOTOPE-EXCHANGE; DEUTERIUM-OXIDE; H/D EXCHANGE; HYDROTHERMAL CONDITION; RHODIUM TRICHLORIDE; HETEROGENEOUS PD/C; HIGH-TEMPERATURE; GENERAL-METHOD; D2O; COMPLEXES;

D O I：

10.1246/bcsj.81.278

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An effective and applicable deuteration method for aromatic rings using Pt/C-D2O-H-2 system was established. Especially, phenol was fully deuterated even at room temperature, and other electron-rich aromatic nuclei were efficiently deuterated under mild conditions. The scope and limitations of the presence method and its application to the synthesis of deuterium-labeled biologically active compounds and deuterium-labeled building blocks for practical multi-gram scale syntheses are reported.

引用

页码：278 / 286

页数：9

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