Practical asymmetric synthesis of vicinal diamines through the catalytic highly enantioselective alkylation of glycine amide derivatives

被引：41

作者：

Ooi, T ^{[1
]}

Sakai, D ^{[1
]}

Takeuchi, M ^{[1
]}

Tayama, E ^{[1
]}

Maruoka, K ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Kyoto 6068502, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 47期

关键词：

alkyl halides; alkylation; asymmetric catalysis; phase-transfer catalysis; vicinal diamines;

D O I：

10.1002/anie.200352658

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phase-transfer catalysis (PTC) by a designer chiral quaternary ammonium bromide facilitated the direct, highly enantioselective introduction of a wide variety of substituents including cycloalkyl side chains at the α position of the prochiral glycine amide derivative 1. A general, practical procedure for the asymmetric synthesis of structurally diverse monosubstituted vicinal diamines of type 2 is presented. Dpm = diphenylmethyl.

引用

页码：5868 / 5870

页数：3

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