Higher recipient body mass index is associated with post-transplant delayed kidney graft function

被引：113

作者：

Molnar, Miklos Z. ^{[1
,2
]}

Kovesdy, Csaba P. ^{[3
,4
]}

Mucsi, Istvan ^{[2
,5
,6
]}

Bunnapradist, Suphamai ^{[7
]}

Streja, Elani ^{[1
]}

Krishnan, Mahesh ^{[8
]}

Kalantar-Zadeh, Kamyar ^{[1
,7
,9
]}

机构：

[1] Univ Calif Los Angeles, Med Ctr, Los Angeles Biomed Res Inst Harbor, Harold Simmons Ctr Chron Dis Res & Epidemiol, Torrance, CA 90509 USA

[2] Semmelweis Univ, Inst Pathophysiol, Budapest, Hungary

[3] Salem VA Med Ctr, Div Nephrol, Salem, VA USA

[4] Univ Virginia, Div Nephrol, Charlottesville, VA USA

[5] McGill Univ, Dept Med, Div Nephrol, Ctr Hlth, Montreal, PQ, Canada

[6] Semmelweis Univ, Inst Behav Sci, Budapest, Hungary

[7] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[8] DaVita Inc, Denver, CO USA

[9] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA

来源：

KIDNEY INTERNATIONAL | 2011年 / 80卷 / 02期

基金：

美国国家卫生研究院;

关键词：

body mass index; delayed graft function; kidney transplantation; obesity; pretransplant weight; weight reduction; RISK-FACTOR; THROMBIN GENERATION; MORBID-OBESITY; TRANSPLANT; SURVIVAL; MORTALITY; IMPACT; ALLOGRAFT; PREDICTABILITY; COMPLICATIONS;

D O I：

10.1038/ki.2011.114

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

To examine whether a higher body mass index (BMI) in kidney recipients is associated with delayed graft function (DGF), we analyzed data from 11,836 hemodialysis patients in the Scientific Registry of Transplant Recipients who underwent kidney transplantation. The patient cohort included women, blacks, and diabetics; the average age was 49 years; and the mean BMI was 26.8 kg/m(2). After adjusting for relevant covariates, multivariate logistic regression analyses found that one standard deviation increase in pretransplant BMI was associated with a higher risk of DGF (odds ratio (OR) 1.35). Compared with patients with a pretransplant BMI of 22-24.99 kg/m(2), overweight patients (BMI 25-29.99 kg/m(2)), mild obesity patients (BMI 30-34.99 kg/m(2)), and moderate-to-severe obesity patients (BMI 35 kg/m(2) and over) had a significantly higher risk of DGF, with ORs of 1.30, 1.42, and 2.18, respectively. Similar associations were found in all subgroups of patients. Hence, pretransplant overweight or obesity is associated with an incrementally higher risk of DGF. Kidney International (2011) 80, 218-224; doi:10.1038/ki.2011.114; published online 27 April 2011

引用

页码：219 / 225

页数：7

共 60 条

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