Erythrocyte margination and sedimentation in skeletal muscle venules

被引:31
作者
Bishop, JJ
Nance, PR
Popel, AS
Intaglietta, M
Johnson, PC [1 ]
机构
[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2001年 / 281卷 / 02期
关键词
venous resistance; low shear flow; in vivo blood rheology; blood sludging; red blood cell core;
D O I
10.1152/ajpheart.2001.281.2.H951
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Previous studies in skeletal muscle of the dog and cat have shown that venous vascular resistance changes inversely with blood flow and may be due mainly to red blood cell aggregation, a phenomenon present in these species. To determine whether red blood cell axial migration and sedimentation contribute to this effect, we viewed either vertically or horizontally oriented venules of the rat spinotrapezius muscle with a horizontally oriented microscope during acute arterial pressure reduction. With normal (nonaggregating) rat blood, reduction of arterial pressure did not significantly change the relative diameter of the red blood cell column with respect to the venular wall. After induction of red blood cell aggregation in the rat by infusion of Dextran 500, red blood cell column diameter decreased up to 35% at low pseudoshear rates (below similar to5 s(-1)); the magnitude was independent of venular orientation. In vertically oriented venules, the plasma layer was symmetrical, whereas in horizontally oriented venules, the plasma layer formed near the upper wall. We conclude that, although red blood cell axial migration and sedimentation develop in vivo, they occur only for larger flow reductions than are needed to elicit changes in venous resistance.
引用
收藏
页码:H951 / H958
页数:8
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