New approach to the coupling of gamma-amino beta-hydroxy acids and beta,gamma-dihydroxy acids with alpha-amino acid esters

被引:20
作者
Palomo, C [1 ]
Miranda, JI [1 ]
Linden, A [1 ]
机构
[1] UNIV ZURICH, INST ORGAN CHEM, CH-8057 ZURICH, SWITZERLAND
关键词
D O I
10.1021/jo961219s
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
alpha,alpha-Dichloro beta-lactones, readily obtained by a highly diastereoselective cycloaddition of dichloroketene to N-Boc-alpha-amino aldehydes and alpha-(silyloxy) aldehydes, coupled efficiently with alpha-amino acid esters leading, after dehalogenation with H-2 over 10% Pd on charcoal, to peptide mimics under mild reaction conditions.
引用
收藏
页码:9196 / 9201
页数:6
相关论文
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