New approach to the coupling of gamma-amino beta-hydroxy acids and beta,gamma-dihydroxy acids with alpha-amino acid esters

被引：20

作者：

Palomo, C ^{[1
]}

Miranda, JI ^{[1
]}

Linden, A ^{[1
]}

机构：

[1] UNIV ZURICH, INST ORGAN CHEM, CH-8057 ZURICH, SWITZERLAND

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 26期

关键词：

D O I：

10.1021/jo961219s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha,alpha-Dichloro beta-lactones, readily obtained by a highly diastereoselective cycloaddition of dichloroketene to N-Boc-alpha-amino aldehydes and alpha-(silyloxy) aldehydes, coupled efficiently with alpha-amino acid esters leading, after dehalogenation with H-2 over 10% Pd on charcoal, to peptide mimics under mild reaction conditions.

引用

页码：9196 / 9201

页数：6

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