An Algorithm for 353 Odor Detection Thresholds in Humans

被引：54

作者：

Abraham, Michael H. ^{[1
]}

Sanchez-Moreno, Ricardo ^{[1
]}

Enrique Cometto-Muniz, J. ^{[2
]}

Cain, William S. ^{[2
]}

机构：

[1] UCL, Dept Chem, London WC1H 0AJ, England

[2] Univ Calif San Diego, Dept Surg Otolaryngol, Chemosensory Percept Lab, La Jolla, CA 92093 USA

来源：

CHEMICAL SENSES | 2012年 / 37卷 / 03期

基金：

美国国家卫生研究院;

关键词：

linear free energy relationships; psychometric odor functions; sensory irritation; volatile organic compounds; VOLATILE ORGANIC-COMPOUNDS; HOMOLOGOUS CARBOXYLIC-ACIDS; EYE IRRITATION THRESHOLDS; FREE-ENERGY ANALYSIS; NASAL PUNGENCY; ALIPHATIC-ALDEHYDES; RESPONSE FUNCTIONS; TRP CHANNEL; N-ALCOHOLS; CHEMESTHESIS;

D O I：

10.1093/chemse/bjr094

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

One hundred and ninety three odor detection thresholds, ODTs, obtained by Nagata using the Japanese triangular bag method can be correlated as log (1/ODT) by a linear equation with R-2 = 0.748 and a standard deviation, SD, of 0.830 log units; the latter may be compared with our estimate of 0.66 log units for the self-consistency of Nagata's data. Aldehydes, acids, unsaturated esters, and mercaptans were included in the equation through indicator variables that took into account the higher potency of these compounds. The ODTs obtained by Cometto-Muniz and Cain, by Cometto-Muniz and Abraham, and by Hellman and Small could be put on the same scale as those of Nagata to yield a linear equation for 353 ODTs with R-2 = 0.759 and SD = 0.819 log units. The compound descriptors are available for several thousand compounds, and can be calculated from structure, so that further ODT values on the Nagata scale can be predicted for a host of volatile or semivolatile compounds.

引用

页码：207 / 218

页数：12

共 58 条

[31] Human olfactory detection of homologous n-alcohols measured via concentration-response functions [J].