Concise Review: Immune Recognition of Induced Pluripotent Stem Cells

被引：69

作者：

Boyd, Ashleigh S. ^{[1
,2
,3
]}

Rodrigues, Neil P. ^{[1
,2
,3
]}

Lui, Kathy O. ^{[4
]}

Fu, Xuemei ^{[5
,6
]}

Xu, Yang ^{[5
]}

机构：

[1] Boston Univ, NIH, Ctr Biomed Res Excellence COBRE Stem Cell Biol, Roger Williams Canc Med Ctr,Sch Med, Providence, RI 02908 USA

[2] Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02118 USA

[3] Boston Univ, Sch Med, Ctr Regenerat Med, Boston, MA 02118 USA

[4] Harvard Univ, Sch Med, Cardiovasc Res Ctr, Massachusetts Gen Hosp, Boston, MA USA

[5] Univ Calif San Diego, Mol Biol Sect, Div Biol Sci, La Jolla, CA 92093 USA

[6] Chengdu Womens & Childrens Cent Hosp, Chengdu, Sichuan, Peoples R China

来源：

STEM CELLS | 2012年 / 30卷 / 05期

关键词：

Stem cells; Embryonic stem cells; Induced pluripotent stem cells; Cell replacement therapy; Immunogenicity; Transplantation; Tolerance; Rejection; Regenerative medicine; REGULATORY T-CELLS; LONG-TERM ACCEPTANCE; DIFFERENTIATED DERIVATIVES; COSTIMULATION BLOCKADE; CARDIAC ALLOGRAFTS; DENDRITIC CELLS; BLOCKING CD40; COPY NUMBER; TGF-BETA; TOLERANCE;

D O I：

10.1002/stem.1066

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Autologous-induced pluripotent stem cells (iPSCs) may eventually be used in cell replacement therapies to treat a wide range of diseases and have been touted as a solution to the vexing problem of immune rejection in this context. Emerging evidence suggests, however, that ostensibly histocompatible iPSCs may be rejected following transplantation. Here, we review the mechanisms that contribute to immunogenicity in iPSCs and forward approaches to permit their acceptance in potential cell replacement therapies. STEM CELLS 2012;30:797803

引用

收藏

页码：797 / 803

页数：7

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