Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells

被引：173

作者：

Reategui, Eduardo ^{[1
,2
,3
]}

Aceto, Nicola ^{[4
]}

Lim, Eugene J. ^{[1
,5
]}

Sullivan, James P. ^{[4
]}

Jensen, Anne E. ^{[1
]}

Zeinali, Mahnaz ^{[1
]}

Martel, Joseph M. ^{[1
,2
,3
]}

Aranyosi, Alexander J. ^{[1
]}

Li, Wei ^{[6
]}

Castleberry, Steven ^{[6
]}

Bardia, Aditya ^{[4
]}

Sequist, Lecia V. ^{[4
]}

Haber, Daniel A. ^{[4
,7
]}

Maheswaran, Shyamala ^{[4
]}

Hammond, Paula T. ^{[6
]}

Toner, Mehmet ^{[1
,2
,3
]}

Stott, Shannon L. ^{[1
,2
,8
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Engn Med, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Shriners Hosp Children, Boston, MA 02114 USA

[3] Harvard Univ, Med Sch 55, Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA

[4] Harvard Univ, Med Sch Boston, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[5] MIT, Dept Elect Engn, Cambridge, MA 02139 USA

[6] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[7] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[8] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 09期

关键词：

EFFICIENT CAPTURE; BREAST-CANCER; MUTATIONS; EGFR;

D O I：

10.1002/adma.201404677

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.

引用

页码：1593 / +

页数：8

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