Chemical modification of arglabin and biological activity of its new derivatives

被引：24

作者：

Adekenov, S. M. ^{[1
]}

机构：

[1] Int Res & Prod Holding Phytochem, Karaganda 100009, Kazakhstan

来源：

FITOTERAPIA | 2016年 / 110卷

关键词：

Artemisia glabella Kar. et Kir; Sesquiterpene lactone arglabin; Structure-activity; Antitumoral; Antifungal; Phagocytosis stimulating; Anti-inflammatory; Antimicrobial activities; Immunomodulatory action;

D O I：

10.1016/j.fitote.2015.11.018

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

This review summarizes the results of own research on chemical modification of the molecule of sesquiterpene lactone arglabin from Artemisia glabella Kar. et Kir. Over 70 new arglabin derivatives were obtained which are polyfunctional compounds with oxy functions, atoms of haloids, phosphorus, nitrogen, and cyclopropane fragments. For the first time the results of bioscreening of new arglabin derivatives are reported. (C) 2015 Published by Elsevier B.V.

引用

页码：196 / 205

页数：10

共 18 条

[1]

Adekenov S. M., 1995, Fitoterapia, V66, P142

[2]

Adekenov S.M., 2012, RUSSIAN BIOTHERAPEUT, V2, P2

[3]

Adekenov S.M., 1992, THESIS I BIOORGANIC

[4]

Adekenov S. M., 1982, CHEM NAT COMPD, V18, P623, DOI DOI 10.1007/BF00575063

[5]

Aituganov K. A., 1991, CHEM NAT COMPD, V27, P27

[6]

Atazhanova G.A., 2008, TERPENOIDS ESSENTIAL

[7]

Synthesis and Biological Evaluation of Antitumor-Active Arglabin Derivatives [J].

Csuk, Rene ;

Heinold, Anke ;

Siewert, Bianka ;

Schwarz, Stefan ;

Barthel, Alexander ;

Kluge, Ralph ;

Stroehl, Dieter .

ARCHIV DER PHARMAZIE, 2012, 345 (03) :215-222

[8]

Preparation and structure elucidation of two minor products from reaction of arglabin with chloroform in the presence of a crown ether [J].

Jalmakhanbetova, R. I. ;

Atazhanova, G. A. ;

Raldugin, V. A. ;

Bagryanskaya, I. Yu. ;

Gatilov, Yu. V. ;

Shakirov, M. M. ;

Adekenov, S. M. .

CHEMISTRY OF NATURAL COMPOUNDS, 2007, 43 (05) :548-551

[9]

Jalmakhanbetova R.I., Innovative patent, Patent No. [RK 17754, 15.07.06, 17754150706]

[10]

Jalmakhanbetova R.I., Innovative patent, Patent No. [RK 17751, 15.07.06, 17751150706]

← 1 2 →