Synthesis and Biological Evaluation of Antitumor-Active Arglabin Derivatives

被引：28

作者：

Csuk, Rene ^{[1
]}

Heinold, Anke ^{[1
]}

Siewert, Bianka ^{[1
]}

Schwarz, Stefan ^{[1
]}

Barthel, Alexander ^{[1
]}

Kluge, Ralph ^{[1
]}

Stroehl, Dieter ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Bereich Organ Chem, D-06120 Halle, Saale, Germany

来源：

ARCHIV DER PHARMAZIE | 2012年 / 345卷 / 03期

关键词：

Arglabin; Arborescin; Antitumor activity; Guaianolides; SCHISTOSOMICIDAL SESQUITERPENE LACTONE; ESTAFIATIN; 1,10-EPIARBORESCIN; STEREOCHEMISTRY; ASSIGNMENT; ARBORESCIN; PRODUCTS;

D O I：

10.1002/ardp.201100065

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Arglabin derivatives varied at the endo- or exo-cyclic double bond were synthesized and studied in a colorimetric sulforhodamine B assay for their cytotoxicity. Variations on the endocyclic double bond led to compounds of reduced cytotoxicity whereas derivatives from the reaction of the alpha-methylene-gamma-butyrolactone moiety led to compounds of similar or only slightly reduced cytotoxicity but different, cell line-dependent selectivity. In addition, arglabin is an excellent starting material for the synthesis of the guaianolide arborescin.

引用

页码：215 / 222

页数：8

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