STUDIES ON THE SYNTHESES OF BIOLOGICALLY-ACTIVE SESQUITERPENE LACTONES

被引：15

作者：

ANDO, M

机构：

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 1992年 / 50卷 / 10期

关键词：

EUDESMANOLIDES; ELEMANOLIDES; GUAIANOLIDES; FRAGMENTATION REACTION; SOLVOLYTIC REARRANGEMENT; BIOLOGICALLY ACTIVE SESQUITERPENE LACTONES;

D O I：

10.5059/yukigoseikyokaishi.50.858

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Many biologically interesting eudesmanolides have been synthesized from commercilly available alpha-santonin and their biological activities have been studies. The eudesmanolides functionalized at C-1 were then demonstrated to be efficient common intermediates for the syntheses of elemanolides and guaianolides. Thus the fragmentation reaction of 36 with Al (i PrO)3 gave a new route to the synthesis of elemanolides and germacranolides. The solvolytic rearrangement of 36, 49, 63, and 99 gave efficient intermediates for the syntheses of naturally occurring guaianolides.

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页码：858 / 874

页数：17

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