Deficiencies in the standardization and sensitivity of diagnostic tests for hepatitis B virus

被引：57

作者：

Gerlich, W. H. ^{[1
]}

Glebe, D. ^{[1
]}

Schuettler, C. G. ^{[1
]}

机构：

[1] Univ Giessen, Inst Med Virol, D-35392 Giessen, Germany

来源：

JOURNAL OF VIRAL HEPATITIS | 2007年 / 14卷

关键词：

anti-HBc; escape mutants; HBsAg; HBV DNA;

D O I：

10.1111/j.1365-2893.2007.00912.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The patterns of hepatitis B virus (HBV) markers described in textbooks apply to acute and chronic infection with wild-type HBV. Deviations from these patterns occur in the very early phase, in low-level (or occult) infection and under immunosuppression. Variability may originate front the virus, the host or the test kits. In order to obtain a reliable diagnosis under these conditions, tests for all three markers of HBV infection have to be applied: HBsAg, HBV DNA and anti-HBc. All tests should be as sensitive as feasible, but even then occult infection may be missed. Reliable detection of occult or mutated HBV is particularly important in blood and organ donors and in patients before or with immunosuppression.

引用

页码：16 / 21

页数：6

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