Biocompatibility of magnesium-zinc alloy in biodegradable orthopedic implants

被引：92

作者：

Chen, Daoyun ^{[1
]}

He, Yaohua ^{[1
]}

Tao, Hairong ^{[1
]}

Zhang, Yan ^{[1
]}

Jiang, Yao ^{[1
]}

Zhang, Xiaonong ^{[2
]}

Zhang, Shaoxiang ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Orthopaed Surg, Shanghai Peoples Hosp 6, Shanghai 200233, Peoples R China

[2] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Sch Mat Sci & Engn, Shanghai 200233, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2011年 / 28卷 / 03期

关键词：

biocompatibility; osteoblast; gene expression; bone remodeling; Mg-Zn alloy; IN-VIVO CORROSION; CELL-ADHESION; OSTEOBLASTIC CELLS; ZN ALLOY; BONE; BEHAVIOR; COLLAGEN; MATRIX; BIOMATERIALS; FIBRONECTIN;

D O I：

10.3892/ijmm.2011.707

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

In this study, magnesium-zinc (Mg-Zn) alloy was investigated as a biodegradable orthopedic implant. MC3T3-E1 cell attachment, mineralization and osteogenic-specific mRNA expression were assessed for as measurements of the in vitro biocompatibility of Mg-Zn alloy. In vivo degradation of the Mg-Zn alloy and the accompanying new bone formation in the femoral marrow cavity were analyzed by scanning electron microscopy and histomorphological analysis. Results showed that MC3T3-E1 cells cultured on Mg-Zn alloy samples manifested better attachment and mineralization ability, as well as improved mRNA expression of collagen 1 alpha 1 (COL1 alpha 1) and osteocalcin (OC), compared with cells seeded on poly-L-lactic acid (PLLA) samples. In vivo experiments demonstrated that, compared with PLLA materials, the Mg-Zn alloy not only degraded faster, but was accompanied by considerable new bone formation around the samples. Our data indicate that Mg-Zn alloy has excellent biocompatibility for application as degradable bone implants.

引用

页码：343 / 348

页数：6

共 34 条

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