Biocompatibility of bio-Mg-Zn alloy within bone with heart, liver, kidney and spleen

被引：105

作者：

He YaoHua ^{[1
]}

Tao HaiRong ^{[1
]}

Zhang Yan ^{[1
]}

Jiang Yao ^{[1
]}

Zhang ShaoXiang ^{[2
]}

Zhao ChangLi ^{[2
]}

Li JiaNan ^{[2
]}

Zhang BeiLei ^{[2
]}

Song Yang ^{[2
]}

Zhang XiaoNong ^{[2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthoped, Shanghai 200233, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China

来源：

CHINESE SCIENCE BULLETIN | 2009年 / 54卷 / 03期

基金：

中国国家自然科学基金;

关键词：

magnesium-zinc alloy; bone; blood magnesium; biocompatibility; intraosseus fixation; IN-VIVO CORROSION; MAGNESIUM ALLOYS;

D O I：

10.1007/s11434-009-0080-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

A magnesium-zinc alloy rod was implanted into the marrow cavity of the distal femur in New Zealand rabbits. The femur with the implanted alloy was compared with the contralateral femur in which a bone tunnel without implant was formed as a control. Degradation of the magnesium-zinc alloy was analyzed via X-ray, scanning electron microscopy, and element energy spectrum analysis. Serum magnesium, liver and kidney function tests, and myocardial enzymes were measured. Heart, liver, kidney and spleen were sectioned for pathological analysis, and the effects of the implanted material on the histology and function of important organs were analyzed. Magnesium-zinc alloy was resorbed from the bone marrow cavity of the femur; 87% of the alloy was degraded within 14 weeks after the surgery. There were no significant differences in serum magnesium, liver or kidney function tests, or myocardial enzymes before the surgery and after degradation of the magnesium-zinc alloy. Histology of the heart, liver, kidney, and spleen did not change. This study demonstrated that magnesium-zinc alloy can be resorbed in bone, and that the degradation products have good biocompatibility with heart, liver, kidney, and spleen.

引用

页码：484 / 491

页数：8

共 12 条

[1]

GREY JE, 2002, J ALLOY COMPD, V336, P88

[2]

Huang JJ, 2007, RARE METAL MAT ENG, V36, P1102

[3]

Bone-like matrix formation on magnesium and magnesium alloys [J].