B cell immunopathology during HIV-1 infection: Lessons to learn for HIV-1 vaccine design

被引：45

作者：

Cagigi, Alberto ^{[1
]}

Nilsson, Anna ^{[1
,2
]}

De Milito, Angelo ^{[3
]}

Chiodi, Francesca ^{[1
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Woman & Child Hlth, Stockholm, Sweden

[3] Ist Super Sanita, Dept Drug Res & Evaluat, I-00161 Rome, Italy

来源：

VACCINE | 2008年 / 26卷 / 24期

关键词：

B cells; HIV-1; vaccination; chemokine receptors;

D O I：

10.1016/j.vaccine.2007.11.063

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Induction of broad HIV-1 neutralizing antibodies should be a major goal of an effective HIV-1 vaccine. However, B cells are severely damaged during HIV-1 infection with loss of memory B cells and decline of serological. memory. The molecular events leading to B cell damage must be further characterized with the aim of selecting vaccine components allowing preservation of B cell functions. This review focuses on B cell damage and antibody responses in HIV-1-infected patients during vaccination studies with viral and bacterial. antigens. In addition novel data indicate that B cell activation may be at the basis of impaired immune responses. (c) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3016 / 3025

页数：10

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