Regulating the adaptive immune response to respiratory virus infection

被引：304

作者：

Braciale, Thomas J. ^{[1
,2
,3
]}

Sun, Jie ^{[1
,3
]}

Kim, Taeg S. ^{[1
,3
]}

机构：

[1] Univ Virginia, Beirne B Carter Ctr Immunol Res, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Microbiol, Charlottesville, VA 22908 USA

[3] Univ Virginia, Dept Pathol, Charlottesville, VA 22908 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CD8(+) T-CELLS; POSTINFLUENZA BACTERIAL PNEUMONIA; CD103(+) DENDRITIC CELLS; INFLUENZA-A VIRUS; MHC CLASS-I; ANTIGEN PRESENTATION; ALVEOLAR MACROPHAGES; EPITHELIAL-CELLS; LYMPH-NODE; PULMONARY IMMUNOPATHOLOGY;

D O I：

10.1038/nri3166

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Recent years have seen several advances in our understanding of immunity to virus infection of the lower respiratory tract, including to influenza virus infection. Here, we review the cellular targets of viruses and the features of the host immune response that are unique to the lungs. We describe the interplay between innate and adaptive immune cells in the induction, expression and control of antiviral immunity, and discuss the impact of the infected lung milieu on moulding the response of antiviral effector T cells. Recent findings on the mechanisms that underlie the increased frequency of severe pulmonary bacterial infections following respiratory virus infection are also discussed.

引用

页码：295 / 305

页数：11

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