Impact of diet on lead in blood and urine in female adults and relevance to mobilization of lead from bone stores

被引:35
作者
Gulson, BL [1 ]
Mahaffey, KR
Jameson, CW
Patison, N
Law, AJ
Mizon, KJ
Korsch, MJ
Pederson, D
机构
[1] Macquarie Univ, Grad Sch Environm, Sydney, NSW 2109, Australia
[2] CSIRO, N Ryde, NSW 2113, Australia
[3] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA
[4] NIEHS, Res Triangle Pk, NC 27709 USA
[5] Univ Canberra, Fac Informat Sci & Engn, Belconnen, ACT 2616, Australia
关键词
adult females; bone; diet; lead isotopes; pregnancy;
D O I
10.2307/3434591
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
We measured high precision lead isotope ratios and lead concentrations in blood, urine, and environmental samples to assess the significance of diet as a contributing factor to blood and urine lead levels in a cohort of 23 migrant women and 5 Australian-born women. We evaluated possible correlations between levels of dietary lead intake and changes observed in blood and urine lead levels and isotopic composition during pregnancy and postpartum. Mean blood lead concentrations for both groups were approximately 3 mu g/dl. The concentration of lead in the diet was 5.8 +/- 3 mu g Pb/kg [geometric mean (GM) 5.2] and mean daily dietary intake was 8.5 mu g/kg/day (GM 7.4), with a range of 2-39 mu g/kg/day. Analysis of 6-day duplicate dietary samples for individual subjects commonly showed major spikes in lead concentration and isotopic composition that were not reflected by associated changes in either blood lead concentration or isotopic composition Changes in blood lead levels and isotopic composition observed during and after pregnancy could not be solely explained by dietary lead. These data are consistent with earlier conclusions that, in cases where levels of environmental lead exposure and dietary lead intake are low, skeletal contribution is the dominant contributor to blood lead, especially during pregnancy and postpartum.
引用
收藏
页码:257 / 263
页数:7
相关论文
共 34 条
[1]  
ADAMS M A, 1991, Chemical Speciation and Bioavailability, V3, P37
[2]  
ANGLE CR, 1995, CLIN TOXICOL, V33, P657
[3]  
BOLGER P M, 1991, Chemical Speciation and Bioavailability, V3, P31
[4]   Updating about reductions of air and blood lead concentrations in Turin, Italy, following reductions in the lead content of gasoline [J].
Bono, R ;
Pignata, C ;
Scursatone, E ;
Rovere, R ;
Natale, P ;
Gilli, G .
ENVIRONMENTAL RESEARCH, 1995, 70 (01) :30-34
[5]   HAZARD ASSESSMENT OF LEAD [J].
CARRINGTON, CD ;
SHEEHAN, DM ;
BOLGER, PM .
FOOD ADDITIVES AND CONTAMINANTS, 1993, 10 (03) :325-335
[6]   PREDICTION OF RESPONSE OF BLOOD LEAD TO AIRBORNE AND DIETARY LEAD FROM VOLUNTEER EXPERIMENTS WITH LEAD ISOTOPES [J].
CHAMBERLAIN, AC .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1985, 224 (1235) :149-182
[7]   Identification of secondary lead sources in the air of an urban environment [J].
Chiaradia, M ;
Gulson, BL ;
James, M ;
Jameson, CW ;
Johnson, D .
ATMOSPHERIC ENVIRONMENT, 1997, 31 (21) :3511-3521
[8]   LEAD INTAKE AND BLOOD LEAD IN 2-YEAR-OLD UK URBAN CHILDREN [J].
DAVIES, DJA ;
THORNTON, I ;
WATT, JM ;
CULBARD, EB ;
HARVEY, PG ;
DELVES, HT ;
SHERLOCK, JC ;
SMART, GA ;
THOMAS, JFA ;
QUINN, MJ .
SCIENCE OF THE TOTAL ENVIRONMENT, 1990, 90 :13-29
[9]  
Delves HT, 1996, BRIT MED J, V313, P883
[10]  
Faure G, 1986, PRINCIPLES ISOTOPE G