Soluble low-density lipoprotein receptor-related protein

被引：15

作者：

Grimsley, PG

Quinn, KA

Owensby, DA ^{[1
]}

机构：

[1] Univ New S Wales, Sch Pathol, Ctr Thrombosis & Vasc Res, Sydney, NSW 2052, Australia

[2] Illawarra Reg Hosp, Wollongong, NSW, Australia

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1998年 / 8卷 / 08期

关键词：

D O I：

10.1016/S1050-1738(98)00029-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Soluble forms of receptors can influence the activity of their membrane-bound counterparts by affecting their interactions with ligands. Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration. We recently identified a soluble form of LRP (sLRP) in human plasma and showed that it retains LRP-ligand binding ability. These findings open potentially important additional aspects in the biology of this multifunctional receptor. This review summarizes characteristics of soluble LRP and relates these to the membrane-bound form of the receptor (Trends Cardiovasc Med 1998;8:363-368) (C) 1998, Elsevier Science Inc.

引用

页码：363 / 368

页数：6

共 43 条

[21] Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, and alpha(1)-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein [J].