IFNγ enhances IL-23 production during Francisella infection of human monocytes

被引：11

作者：

Butchar, Jonathan P. ^{[1
]}

Parsa, Kishore V. L. ^{[1
]}

Marsh, Clay B. ^{[1
]}

Tridandapani, Susheela ^{[1
]}

机构：

[1] Ohio State Univ, Dept Internal Med, Div Pulm & Crit Care, Columbus, OH 43210 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 07期

关键词：

host response; IL-23; monocytes; Francisella;

D O I：

10.1016/j.febslet.2008.02.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously demonstrated that monocytes produce IL-23 during Francisella infection, and that IL-23 induces IFN gamma from NK cells. Here, we demonstrate that IFN gamma-priming of monocytes enhances IL-23 production during Francisella infection. This effect was seen on the IL12/23 p40 subunit. Induction of IL-12/23 p40 is reported to be enhanced by IRF-1 and IRF-8. Consistently, microarray analysis of IFN gamma-treated monocytes revealed a significant induction of the IRFs. Interestingly, IFN gamma-primed monocytes produced IL-12 p70, a more potent inducer of IFN gamma than IL-23. We propose that there exists an amplification loop between monocyte IL-23 and NK/T cell IFN gamma that leads to IL-12 p70 production. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1044 / 1048

页数：5

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