An esterase-activated magnetic resonance contrast agent

被引：48

作者：

Giardiello, Marco

Lowe, Mark P.

Botta, Mauro

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

[2] Univ Piemonte Orientale, Dipartimento Sci Ambiente & Vita, I-15100 Alessandria, Italy

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 39期

关键词：

D O I：

10.1039/b711989e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Gd(III) complex bearing pendant acetoxymethyl esters is activated on exposure to porcine liver esterase; the 84% increase in relaxivity is a result of suppression of HCO3-/CO32- binding by the resulting negative charge.

引用

页码：4044 / 4046

页数：3

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