The synthesis of diaminopimelic acid containing peptidoglycan fragments using metathesis cross coupling

被引：44

作者：

Chowdhury, AR ^{[1
]}

Boons, GJ ^{[1
]}

机构：

[1] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 10期

基金：

美国国家卫生研究院;

关键词：

peptidoglycan; amino acid; cross metathesis; meso-2,6-diaminopimelic acid;

D O I：

10.1016/j.tetlet.2005.01.062

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Properly protected diaminopimelic acid (DAP), a component of peptidoglycan of Gram-negative bacteria, was prepared by a metathesis cross coupling between properly protected allyl and vinyl glycine derivatives using Grubb's second-generation catalyst followed by reduction of the double bond of the resulting Compound. The DAP derivatives were used in the solution and polymer-supported synthesis of biological active peptides. (C) 2005 Published by Elsevier Ltd.

引用

页码：1675 / 1678

页数：4

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