Antigenic and molecular characterization of rabies virus in Argentina

被引：45

作者：

Cisterna, D ^{[1
]}

Bonaventura, R

Caillou, S

Pozo, O

Andreau, ML

Fontana, LD

Echegoyen, C

de Mattos, C

Russo, S

Novaro, L

Elberger, D

Freire, MC

机构：

[1] ANLIS Dr carlos G Malbran, Inst Nacl Enfermed Infecciosas, Serv Neurovirosis, Buenos Aires, DF, Argentina

[2] Div Zoonosis, San Miguel De Tucuman, Argentina

[3] Minist Salud, Div Zoonosis Urbana, Buenos Aires, DF, Argentina

[4] Lab Reg Diagnost Rabia, Chaco, Argentina

[5] Lab Zoonosis, Santa Fe, Argentina

[6] Direcc Nacl Epidemiol, Buenos Aires, DF, Argentina

[7] CDC, Rabies Sect, Atlanta, GA 30333 USA

[8] SENASA, DILACOT, Buenos Aires, DF, Argentina

来源：

VIRUS RESEARCH | 2005年 / 109卷 / 02期

关键词：

rabies; antigenic variant; molecular epidemiology;

D O I：

10.1016/j.virusres.2004.10.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleoprotein genes of 54 human, domestic and wild animals rabies isolates obtained in Argentina between 1995 and 2002 were characterized using monoclonal antibodies and partial gene sequence analysis. The antigenic and genetic diversities of rabies virus ill samples from bat and bat-related cases were studied, leading to the identification of five distinct genetic variants. Rabies viruses isolated from vampire bat related cases were very similar to each other. showing 98.9% overall similarity. Specific antigenic variants (AgV) were detected associated with different insectivorous bats species, in samples from Tadarida brasiliensis and Emnops patagonicus bats. In contrast, isolates from Myotis sp. and Histiotus sp. bats could not be matched to any antigenic type. Additionally, bat rabies cases were also detected in southern provinces previously considered rabies-free. Finally, two independent antigenic and genetic variants co-circulating in northern Argentina were found in isolates obtained from dogs and dog-related cases, suggesting two independent cycles of virus transmission. This is the first national coordinated Study of antigenic as well as molecular epidemiology of rabies in Argentina. The information presented here will improve our knowledge about rabies epidemiology and therefore, will assist preventing fatal human cases. (c) 2004 Elsevier B.V. All rights reserved.

引用

页码：139 / 147

页数：9

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