Seleno compounds and glutathione peroxidase catalyzed decomposition of S-nitrosothiols

被引：132

作者：

Hou, YC ^{[1
]}

Guo, ZM ^{[1
]}

Li, J ^{[1
]}

Wang, PG ^{[1
]}

机构：

[1] UNIV MIAMI,DEPT CHEM,CORAL GABLES,FL 33124

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 228卷 / 01期

关键词：

D O I：

10.1006/bbrc.1996.1620

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seleno compounds such as selenocystamine and seleno-D, L-cystine were found to catalyze the decomposition of S-nitrosothiols (e.g. S-nitroso-glutathione and S-nitroso-N-acetyl-D, L-penicillamine) in the presence of different thiols (e.g. glutathione,N-acetyl-D-peniciliamine and 2-mercaptoethanol), and liberate nitric oxide. It was also found that glutathione peroxidase itself can catalyze the decomposition of S-nitrosoglutathione without the presence of any thiol or H2O2. (C) 1996 Academic Press, Inc.

引用

页码：88 / 93

页数：6