Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia

被引:1342
作者
Lauretani, F
Russo, CR
Bandinelli, S
Bartali, B
Cavazzini, C
Di Iorio, A
Corsi, AM
Rantanen, T
Guralnik, JM
Ferrucci, L
机构
[1] Italian Natl Inst Res & Care Aging, Dept Geriatr, Lab Clin Epidemiol, I-50125 Florence, Italy
[2] Univ G dAnnunzio, Geriatr Clin, Dept Med & Aging, I-66013 Chieti, Italy
[3] Univ Jyvaskyla, Dept Hlth Sci, Jyvaskyla 40351, Finland
[4] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
[5] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA
关键词
elderly; muscle power; strength;
D O I
10.1152/japplphysiol.00246.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Sarcopenia, the reduction of muscle mass and strength that occurs with aging, is widely considered one of the major causes of disability in older persons. Surprisingly, criteria that may help a clinician to identify persons with impaired muscle function are still lacking. Using data from a large representative sample of the general population, we examined how muscle function and calf muscle area change with aging and affect mobility in men and women free of neurological conditions. We tested several putative indicators of sarcopenia, including knee extension isometric torque, handgrip, lower extremity muscle power, and calf muscle area. For each indicator, sarcopenia was considered to be present when the measure was >2 SDs below the mean. For all four measures, the prevalence of sarcopenia increased with age, both in men and women. The age-associated gradient in prevalence was maximum for muscle power and minimum for calf-muscle area. However, lower extremity muscle power was no better than knee-extension torque or handgrip in the early identification of poor mobility, defined either as walking speed <0.8 m/s or inability to walk at least 1 km without difficulty and without developing symptoms. Optimal cutoff values that can be used in the clinical practice to identify older persons with poor mobility were developed. The findings of the study lay the basis for a cost-effective, clinical marker of sarcopenia based on a measure of isometric handgrip strength. Our findings should be verified in a longitudinal study.
引用
收藏
页码:1851 / 1860
页数:10
相关论文
共 37 条
[1]   Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans [J].
Balagopal, P ;
Rooyackers, OE ;
Adey, DB ;
Ades, PA ;
Nair, KS .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1997, 273 (04) :E790-E800
[2]   Measuring muscular strength of the lower limbs by hand-held dynamometer: A standard protocol [J].
Bandinelli, S ;
Benvenuti, E ;
Del Lungo, I ;
Baccini, M ;
Benvenuti, F ;
Di Iorio, A ;
Ferrucci, L .
AGING-CLINICAL AND EXPERIMENTAL RESEARCH, 1999, 11 (05) :287-293
[3]   LEG EXTENSOR POWER AND FUNCTIONAL PERFORMANCE IN VERY OLD MEN AND WOMEN [J].
BASSEY, EJ ;
FIATARONE, MA ;
ONEILL, EF ;
KELLY, M ;
EVANS, WJ ;
LIPSITZ, LA .
CLINICAL SCIENCE, 1992, 82 (03) :321-327
[4]   A NEW METHOD FOR MEASURING POWER OUTPUT IN A SINGLE LEG EXTENSION - FEASIBILITY, RELIABILITY AND VALIDITY [J].
BASSEY, EJ ;
SHORT, AH .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 1990, 60 (05) :385-390
[5]   Epidemiology of sarcopenia among the elderly in New Mexico [J].
Baumgartner, RN ;
Koehler, KM ;
Gallagher, D ;
Romero, L ;
Heymsfield, SB ;
Ross, RR ;
Garry, PJ ;
Lindeman, RD .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1998, 147 (08) :755-763
[6]   LONGITUDINAL AND CROSS-SECTIONAL ASSESSMENTS OF AGE-CHANGES IN PHYSICAL STRENGTH AS RELATED TO SEX, SOCIAL-CLASS, AND MENTAL-ABILITY [J].
CLEMENT, FJ .
JOURNALS OF GERONTOLOGY, 1974, 29 (04) :423-429
[7]   Molecular mechanisms and therapeutics of the deficit in specific force in ageing skeletal muscle [J].
Delbono, O .
BIOGERONTOLOGY, 2002, 3 (05) :265-270
[8]   COMPARING THE AREAS UNDER 2 OR MORE CORRELATED RECEIVER OPERATING CHARACTERISTIC CURVES - A NONPARAMETRIC APPROACH [J].
DELONG, ER ;
DELONG, DM ;
CLARKEPEARSON, DI .
BIOMETRICS, 1988, 44 (03) :837-845
[9]  
Evans W, 1997, J NUTR, V127, pS998
[10]   WHAT IS SARCOPENIA [J].
EVANS, WJ .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 1995, 50 :5-8