Effects of the bone marrow microenvironment on hematopoietic malignancy

被引：31

作者：

Askmyr, Maria ^{[1
]}

Quach, Julie ^{[1
]}

Purton, Louise E. ^{[1
,2
]}

机构：

[1] St Vincents Inst, Fitzroy, Vic 3065, Australia

[2] Univ Melbourne, Dept Med, Fitzroy, Vic 3065, Australia

来源：

BONE | 2011年 / 48卷 / 01期

基金：

英国医学研究理事会;

关键词：

Bone marrow microenvironment; hematopoiesis; hematopoietic diseases; myeloproliferation; SYMPATHETIC-NERVOUS-SYSTEM; STEM-CELL NICHE; ACUTE-LEUKEMIA; DIFFERENTIATION; INNERVATION; AML1-ETO; DISEASE; STROMA; MICE; TRANSPLANTATION;

D O I：

10.1016/j.bone.2010.06.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The bone marrow (BM) is contained within the bone cavity and is the main site of hematopoiesis, the continuous development of blood cells from immature hematopoietic stem and progenitor cells. The bone marrow consists of developing hematopoietic cells and non-hematopoietic cells, the latter collectively termed the bone marrow microenvironment. These non-hematopoietic cells include cells of the osteoblast lineage, adipocytes and endothelial cells. For many years these bone marrow microenvironment cells were predicted to play active roles in regulating hematopoiesis, and recent studies have confirmed such roles. Importantly, more recent data has indicated that cells of the BM microenvironment may also contribute to hematopoietic diseases. In this review we provide an overview of the roles of the data suggesting that the cells of the bone marrow microenvironment may play an active role in the initiation and progression of hematopoietic malignancy. 2010 Elsevier Inc. All rights reserved.

引用

页码：115 / 120

页数：6

共 77 条

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