Molecules targeting the purine salvage pathway in apicomplexan parasites

被引：17

作者：

Gherardi, Arnaud ^{[1
]}

Sarciron, Marie-Elisabeth ^{[1
]}

机构：

[1] Univ Lyon 1, Pharmaceut Dept Parasitol & Med Mycol, F-69373 Lyon 08, France

来源：

TRENDS IN PARASITOLOGY | 2007年 / 23卷 / 08期

关键词：

D O I：

10.1016/j.pt.2007.06.003

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The need of intracellular parasites to retrieve nutrients and fulfill their energy requirements is achieved by manipulating the host's metabolism. With the spread of AIDS, research on purine metabolism has gained in importance with the aim to develop drugs against opportunistic infections. Many studies over the past ten years have yielded contradictory results, but this review tries to clarify these findings by exposing the latest data concerning purine transport and the specific activities of the major enzymes of the purine salvage pathway of Toxoplasma gondii, Plasmodium falciparum and Cryptosporidium parvum.

引用

页码：384 / 389

页数：6

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