Malaria Vaccine Design: Immunological Considerations

被引：78

作者：

Good, Michael F. ^{[1
,2
]}

Doolan, Denise L. ^{[1
]}

机构：

[1] Queensland Inst Med Res, Div Immunol, Brisbane, Qld 4006, Australia

[2] Griffith Univ, Inst Glyc, Gold Coast, Qld 4222, Australia

来源：

IMMUNITY | 2010年 / 33卷 / 04期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

BLOOD-STAGE MALARIA; T-CELL RESPONSES; MEROZOITE SURFACE PROTEIN-1; PLASMODIUM-FALCIPARUM MALARIA; CD8-ALPHA(+) DENDRITIC CELLS; APICAL MEMBRANE ANTIGEN-1; CROSS-SPECIES REGULATION; CIRCUMSPOROZOITE PROTEIN; LIVER STAGES; IN-VITRO;

D O I：

10.1016/j.immuni.2010.10.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The concept of a malaria vaccine has sparked great interest for decades, however, the challenge is proving to be a difficult one Immune dysregulation by Plasmodium and the ability of the parasite to mutate critical epitopes in surface antigens have proved to be strong defense weapons This has led to reconsideration of polyvalent and whole parasite strategies and ways to enhance cellular immunity to malaria that may be more likely to target conserved antigens and an expanded repertoire of antigens These and other concepts will be discussed in this review

引用

页码：555 / 566

页数：12

共 141 条

[1] Prolonged Th1-like response generated by a Plasmodium yoelii-specific T cell clone allows complete clearance of infection in reconstituted mice [J].

Amante, FH ;

Good, MF .

PARASITE IMMUNOLOGY, 1997, 19 (03) :111-126

[2] Quantitative imaging of Plasmodium transmission from mosquito to mammal [J].

Amino, R ;

Thiberge, S ;

Martin, B ;

Celli, S ;

Shorte, S ;

Frischknecht, F ;

Ménard, R .

NATURE MEDICINE, 2006, 12 (02) :220-224

[3] Heterologous Protein Expression Is Enhanced by Harmonizing the Codon Usage Frequencies of the Target Gene with those of the Expression Host [J].

Angov, Evelina ;

Hillier, Collette J. ;

Kincaid, Randall L. ;

Lyon, Jeffrey A. .

PLOS ONE, 2008, 3 (05)

[4] Release of hepatic Plasmodium yoelii merozoites into the pulmonary microvasculature [J].

Baer, Kerstin ;

Klotz, Christian ;

Kappe, Stefan H. I. ;

Schnieder, Thomas ;

Frevert, Ute .

PLOS PATHOGENS, 2007, 3 (11) :1651-1668

[5] Seasonal malaria attack rates in infants and young children in northern Ghana [J].

Baird, JK ;

Agyei, SO ;

Utz, GC ;

Koram, K ;

Barcus, MJ ;

Jones, TR ;

Fryauff, DJ ;

Binka, FN ;

Hoffman, SL ;

Nkrumah, FN .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2002, 66 (03) :280-286

[6] Age-dependent characteristics of protection v. susceptibility to Plasmodium falciparum [J].

Baird, JK .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1998, 92 (04) :367-390

[7]

BALLOU WR, 1987, LANCET, V1, P1277

[8] Contrasting Population Structures of the Genes Encoding Ten Leading Vaccine-Candidate Antigens of the Human Malaria Parasite, Plasmodium falciparum [J].

Barry, Alyssa E. ;

Schultz, Lee ;

Buckee, Caroline O. ;

Reeder, John C. .

PLOS ONE, 2009, 4 (12)

[9] CLONING THE PLASMODIUM-FALCIPARUM GENE ENCODING PFEMP1, A MALARIAL VARIANT ANTIGEN AND ADHERENCE RECEPTOR ON THE SURFACE OF PARASITIZED HUMAN ERYTHROCYTES [J].

BARUCH, DI ;

PASLOSKE, BL ;

SINGH, HB ;

BI, XH ;

MA, XC ;

FELDMAN, M ;

TARASCHI, TF ;

HOWARD, RJ .

CELL, 1995, 82 (01) :77-87

[10] Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells [J].

Bedoui, Sammy ;

Whitney, Paul G. ;

Waithman, Jason ;

Eidsmo, Liv ;

Wakim, Linda ;

Caminschi, Irina ;

Allan, Rhys S. ;

Wojtasiak, Magdalena ;

Shortman, Ken ;

Carbone, Francis R. ;

Brooks, Andrew G. ;

Heath, William R. .

NATURE IMMUNOLOGY, 2009, 10 (05) :488-495

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