Malaria Vaccine Design: Immunological Considerations

被引：78

作者：

Good, Michael F. ^{[1
,2
]}

Doolan, Denise L. ^{[1
]}

机构：

[1] Queensland Inst Med Res, Div Immunol, Brisbane, Qld 4006, Australia

[2] Griffith Univ, Inst Glyc, Gold Coast, Qld 4222, Australia

来源：

IMMUNITY | 2010年 / 33卷 / 04期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

BLOOD-STAGE MALARIA; T-CELL RESPONSES; MEROZOITE SURFACE PROTEIN-1; PLASMODIUM-FALCIPARUM MALARIA; CD8-ALPHA(+) DENDRITIC CELLS; APICAL MEMBRANE ANTIGEN-1; CROSS-SPECIES REGULATION; CIRCUMSPOROZOITE PROTEIN; LIVER STAGES; IN-VITRO;

D O I：

10.1016/j.immuni.2010.10.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The concept of a malaria vaccine has sparked great interest for decades, however, the challenge is proving to be a difficult one Immune dysregulation by Plasmodium and the ability of the parasite to mutate critical epitopes in surface antigens have proved to be strong defense weapons This has led to reconsideration of polyvalent and whole parasite strategies and ways to enhance cellular immunity to malaria that may be more likely to target conserved antigens and an expanded repertoire of antigens These and other concepts will be discussed in this review

引用

页码：555 / 566

页数：12

共 141 条

[91] PROTECTIVE IMMUNITY PRODUCED BY INJECTION OF X-IRRADIATED SPOROZOITES OF PLASMODIUM BERGHEI [J].

NUSSENZWEIG, RS ;

VANDERBERG, J ;

MOST, H ;

ORTON, C .

NATURE, 1967, 216 (5111) :160-+

[92] Blood Stage Malaria Vaccine Eliciting High Antigen-Specific Antibody Concentrations Confers No Protection to Young Children in Western Kenya [J].

Ogutu, Bernhards R. ;

Apollo, Odika J. ;

McKinney, Denise ;

Okoth, Willis ;

Siangla, Joram ;

Dubovsky, Filip ;

Tucker, Kathryn ;

Waitumbi, John N. ;

Diggs, Carter ;

Wittes, Janet ;

Malkin, Elissa ;

Leach, Amanda ;

Soisson, Lorraine A. ;

Milman, Jessica B. ;

Otieno, Lucas ;

Holland, Carolyn A. ;

Polhemus, Mark ;

Remich, Shon A. ;

Ockenhouse, Christian F. ;

Cohen, Joe ;

Ballou, W. Ripley ;

Martin, Samuel K. ;

Angov, Evelina ;

Stewart, V. Ann ;

Lyon, Jeffrey A. ;

Heppner, D. Gray, Jr. ;

Withers, Mark R. .

PLOS ONE, 2009, 4 (03)

[93]

Olugbile S, 2010, CURR OPIN MOL THER, V12, P64

[94] Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria [J].

Osier, Faith H. A. ;

Fegan, Gregory ;

Polley, Spencer D. ;

Murungi, Linda ;

Verra, Federica ;

Tetteh, Kevin K. A. ;

Lowe, Brett ;

Mwangi, Tabitha ;

Bull, Peter C. ;

Thornas, Alan W. ;

Cavanagh, David R. ;

McBride, Jana S. ;

Lanar, David E. ;

Mackinnon, Margaret J. ;

Conway, David J. ;

Marsh, Kevin .

INFECTION AND IMMUNITY, 2008, 76 (05) :2240-2248

[95] Protective CD8+ T cells against Plasmodium liver stages:: immunobiology of an 'unnatural' immune response [J].

Overstreet, Michael Glen ;

Cockbum, Ian Andrew ;

Chen, Yun-Chi ;

Zavala, Fidel .

IMMUNOLOGICAL REVIEWS, 2008, 225 :272-283

[96]

OWUSU AS, 2001, AM J TROP MED HYG, V65, P197

[97] Understanding B cell activation: from single molecule tracking, through Tolls, to stalking memory in malaria [J].

Pierce, Susan K. .

IMMUNOLOGIC RESEARCH, 2009, 43 (1-3) :85-97

[98] Low doses of killed parasite in CpG elicit vigorous CD4+ T cell responses against blood-stage malaria in mice [J].

Pinzon-Charry, Alberto ;

McPhun, Virginia ;

Kienzle, Vivian ;

Hirunpetcharat, Chakrit ;

Engwerda, Christian ;

McCarthy, James ;

Good, Michael F. .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (08) :2967-2978

[99] The Potential Role of Vaccines in the Elimination of Falciparum Malaria and the Eventual Eradication of Malaria [J].

Plowe, Christopher V. ;

Alonso, Pedro ;

Hoffman, Stephen L. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 200 (11) :1646-1649

[100] Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum [J].

Pombo, DJ ;

Lawrence, G ;

Hirunpetcharat, C ;

Rzepczyk, C ;

Bryden, M ;

Cloonan, N ;

Anderson, K ;

Mahakunkijcharoen, Y ;

Martin, LB ;

Wilson, D ;

Elliott, S ;

Eisen, DP ;

Weinberg, JB ;

Saul, A ;

Good, MF .

LANCET, 2002, 360 (9333) :610-617

← 5 6 7 8 9 10 11 12 13 14 →