Malaria Vaccine Design: Immunological Considerations

被引：78

作者：

Good, Michael F. ^{[1
,2
]}

Doolan, Denise L. ^{[1
]}

机构：

[1] Queensland Inst Med Res, Div Immunol, Brisbane, Qld 4006, Australia

[2] Griffith Univ, Inst Glyc, Gold Coast, Qld 4222, Australia

来源：

IMMUNITY | 2010年 / 33卷 / 04期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

BLOOD-STAGE MALARIA; T-CELL RESPONSES; MEROZOITE SURFACE PROTEIN-1; PLASMODIUM-FALCIPARUM MALARIA; CD8-ALPHA(+) DENDRITIC CELLS; APICAL MEMBRANE ANTIGEN-1; CROSS-SPECIES REGULATION; CIRCUMSPOROZOITE PROTEIN; LIVER STAGES; IN-VITRO;

D O I：

10.1016/j.immuni.2010.10.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The concept of a malaria vaccine has sparked great interest for decades, however, the challenge is proving to be a difficult one Immune dysregulation by Plasmodium and the ability of the parasite to mutate critical epitopes in surface antigens have proved to be strong defense weapons This has led to reconsideration of polyvalent and whole parasite strategies and ways to enhance cellular immunity to malaria that may be more likely to target conserved antigens and an expanded repertoire of antigens These and other concepts will be discussed in this review

引用

页码：555 / 566

页数：12

共 141 条

[121] Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A [J].

Spring, Michele D. ;

Cummings, James F. ;

Ockenhouse, Christian F. ;

Dutta, Sheetij ;

Reidler, Randall ;

Angov, Evelina ;

Bergmann-Leitner, Elke ;

Stewart, V. Ann ;

Bittner, Stacey ;

Juompan, Laure ;

Kortepeter, Mark G. ;

Nielsen, Robin ;

Krzych, Urszula ;

Tierney, Ev ;

Ware, Lisa A. ;

Dowler, Megan ;

Hermsen, Cornelus C. ;

Sauerwein, Robert W. ;

de Vlas, Sake J. ;

Ofori-Anyinam, Opokua ;

Lanar, David E. ;

Williams, Jack L. ;

Kester, Kent E. ;

Tucker, Kathryn ;

Shi, Meng ;

Malkin, Elissa ;

Long, Carole ;

Diggs, Carter L. ;

Soisson, Lorraine ;

Dubois, Marie-Claude ;

Ballou, W. Ripley ;

Cohen, Joe ;

Heppner, D. Gray, Jr. .

PLOS ONE, 2009, 4 (04)

[122] Pattern of malaria-specific T-cell responses in a cohort of Ugandan children [J].

Ssewanyana, Isaac ;

Pietras, Christopher ;

Baker, Chris A. R. ;

Nghania, Frehd ;

Jones, Norman G. ;

Rosenthal, Philip J. ;

Dorsey, Grant ;

Cao, Huyen .

JOURNAL OF TROPICAL PEDIATRICS, 2008, 54 (01) :6-13

[123] Innate immunity to malaria [J].

Stevenson, MM ;

Riley, EM .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (03) :169-180

[124] Priming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS,S/AS01B boosting significantly improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone [J].

Stewart, V. Ann ;

McGrath, Shannon M. ;

Dubois, Patrice M. ;

Pau, Maria G. ;

Mettens, Pascal ;

Shott, Joseph ;

Cobb, Michelle ;

Burge, J. Robert ;

Larson, David ;

Ware, Lisa A. ;

Demoitie, Marie-Ange ;

Weverling, Gerrit Jan ;

Bayat, Babak ;

Custers, Jerome H. H. V. ;

Dubois, Marie-Claude ;

Cohen, Joe ;

Goudsmit, Jaap ;

Heppner, D. Gray, Jr. .

INFECTION AND IMMUNITY, 2007, 75 (05) :2283-2290

[125] Vaccination with novel immunostimulatory adjuvants against blood-stage malaria in mice [J].

Su, Z ;

Tam, MF ;

Jankovic, D ;

Stevenson, MM .

INFECTION AND IMMUNITY, 2003, 71 (09) :5178-5187

[126] Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali [J].

Takala, Shannon L. ;

Coulibaly, Drissa ;

Thera, Mahamadou A. ;

Dicko, Alassane ;

Smith, David L. ;

Guindo, Ando B. ;

Kone, Abdoulaye K. ;

Traore, Karim ;

Ouattara, Amed ;

Djimde, Abdoulaye A. ;

Sehdev, Paul S. ;

Lyke, Kirsten E. ;

Diallo, Dapa A. ;

Doumbo, Ogobara K. ;

Plowe, Christopher V. .

PLOS MEDICINE, 2007, 4 (03) :523-534

[127] Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria:: A prospective study in Papua, Indonesia [J].

Tjitra, Emiliana ;

Anstey, Nicholas M. ;

Sugiarto, Paulus ;

Warikar, Noah ;

Kenangalem, Enny ;

Karyana, Muhammad ;

Lampah, Daniel A. ;

Price, Ric N. .

PLOS MEDICINE, 2008, 5 (06) :890-899

[128]

TRAGER W, 1976, SCIENCE, V193, P673, DOI 10.1126/science.781840

[129] A retrospective evaluation of the role of T cells in the development of malaria vaccine [J].

Tsuji, Moriya .

EXPERIMENTAL PARASITOLOGY, 2010, 126 (03) :421-425

[130] Malaria parasite pre-erythrocytic stage infection: Gliding and hiding [J].

Vaughan, Ashley M. ;

Aly, Ahmed S. I. ;

Kappe, Stefan H. I. .

CELL HOST & MICROBE, 2008, 4 (03) :209-218

← 6 7 8 9 10 11 12 13 14 15 →