Induction of Gag-specific T-cell responses by therapeutic immunization with a Gag-expressing Sendai virus vector in macaques chronically infected with simian-human immunodeficiency virus

被引：17

作者：

Kato, M

Igarashi, H

Takeda, A

Sasaki, Y

Nakamura, H

Kano, M

Sata, T

Iida, A

Hasegawa, M

Horie, S

Higashihara, E

Nagai, Y

Matano, T

机构：

[1] Univ Tokyo, Dept Microbiol, Grad Sch Med, Bunkyo Ku, Tokyo 1130033, Japan

[2] Kyorin Univ, Sch Med, Dept Urol, Mitaka, Tokyo 1818611, Japan

[3] Natl Inst Infect Dis, Ctr AIDS Res, Shinjuku Ku, Tokyo 1628640, Japan

[4] DNAVEC Res Inc, Tsukuba, Ibaraki 3050856, Japan

[5] Teikyo Univ, Sch Med, Dept Urol, Tokyo 1738605, Japan

[6] Toyama Inst Hlth, Toyama 9390363, Japan

来源：

VACCINE | 2005年 / 23卷 / 24期

关键词：

AIDS; Sendai virus; therapeutic vaccine;

D O I：

10.1016/j.vaccine.2004.12.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent prophylactic vaccine trials inducing virus-specific CD8(+) T-cell responses have shown control of primary infections of a pathogenic simian-human immunodeficiency virus (SHIV) in macaques. In the chronic phase, therapeutic immunization replenishing virus-specific CD8(+) T-cells is likely to contribute to sustained control of virus replication. In this study, we have administered a recombinant Sendai virus (SeV) vector into five rhesus macaques that had received prophylactic vaccinations and had controlled SHIV replication for more than 1 year after challenge. Our results indicate that virus-specific CD8(+) T-cell responses can be expanded and broadened by therapeutic immunization with SeV vectors in the chronic phase after prophylactic vaccine-based control of primary immunodeficiency virus infections. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3166 / 3173

页数：8

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