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The role of CD4+ T helper cells in the cytotoxic T lymphocyte response to HIV-1

被引：125
作者：
Altfeld, M
Rosenberg, ES
机构：
[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02114 USA
[2] Harvard Univ, Sch Med, Charlestown, MA 02114 USA
[3] Massachusetts Gen Hosp, Infect Dis Unit, Boston, MA 02114 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 04期
关键词：
D O I：
10.1016/S0952-7915(00)00103-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Virus-specific CD4(+) T cell help and CD8(+) cytotoxic T cell (CTL) responses are critical for the maintenance of effective immunity in chronic viral infections. HIV-1 infection presents a unique situation in which HIV-l-specific T helper cell responses are characteristically impaired and virus-specific CTLs wane over time as disease progresses; a relationship exists between T cell help and Cn responses in HIV-1 infection.
引用
收藏
页码：375 / 380
页数：6
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