Impulsivity is the tendency to act prematurely without foresight. Behavioral and neurobiological analysis of this construct, with evidence from both animal and human studies, defines several dissociable forms depending on distinct cortico-striatal substrates. One form of impulsivity depends on the temporal discounting of reward, another on motor or response disinhibition. Impulsivity is commonly associated with addiction to drugs from different pharmacological classes, but its causal role in human addiction is unclear. We characterize in neurobehavioral and neurochemical terms a rodent model of impulsivity based on premature responding in an attentional task. Evidence is surveyed that high impulsivity on this task precedes the escalation subsequently of cocaine self-administration behavior, and also a tendency toward compulsive cocaine-seeking and to relapse. These results indicate that the vulnerability to stimulant addiction may depend on an impulsivity endophenotype. Implications of these findings for the etiology, development, and treatment of drug addiction are considered.
机构:
Scripps Res Inst, Dept Neuropharmacol, Div Psychopharmacol, La Jolla, CA 92037 USAScripps Res Inst, Dept Neuropharmacol, Div Psychopharmacol, La Jolla, CA 92037 USA
Ahmed, SH
;
Koob, GF
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机构:
Scripps Res Inst, Dept Neuropharmacol, Div Psychopharmacol, La Jolla, CA 92037 USAScripps Res Inst, Dept Neuropharmacol, Div Psychopharmacol, La Jolla, CA 92037 USA
机构:
Hacettepe Univ, Fac Med, Dept Psychiat, TR-06100 Ankara, Turkey
Univ Maastricht, Fac Hlth Med & Life Sci, Dept Neurosci, Maastricht, Netherlands
European Grad Sch Neurosci EURON, Maastricht, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Basar, Koray
;
Sesia, Thibaut
论文数: 0引用数: 0
h-index: 0
机构:
Maastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Univ Maastricht, Fac Hlth Med & Life Sci, Dept Neurosci, Maastricht, Netherlands
European Grad Sch Neurosci EURON, Maastricht, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Sesia, Thibaut
;
Groenewegen, Henk
论文数: 0引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Anat & Neurosci, Amsterdam, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Groenewegen, Henk
;
Steinbusch, Harry W. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maastricht, Fac Hlth Med & Life Sci, Dept Neurosci, Maastricht, Netherlands
European Grad Sch Neurosci EURON, Maastricht, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Steinbusch, Harry W. M.
;
Visser-Vandewalle, Veerle
论文数: 0引用数: 0
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机构:
Maastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
European Grad Sch Neurosci EURON, Maastricht, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Visser-Vandewalle, Veerle
;
Temel, Yasin
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机构:
Maastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Univ Maastricht, Fac Hlth Med & Life Sci, Dept Neurosci, Maastricht, Netherlands
European Grad Sch Neurosci EURON, Maastricht, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
机构:
Scripps Res Inst, Dept Neuropharmacol, Div Psychopharmacol, La Jolla, CA 92037 USAScripps Res Inst, Dept Neuropharmacol, Div Psychopharmacol, La Jolla, CA 92037 USA
Ahmed, SH
;
Koob, GF
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Neuropharmacol, Div Psychopharmacol, La Jolla, CA 92037 USAScripps Res Inst, Dept Neuropharmacol, Div Psychopharmacol, La Jolla, CA 92037 USA
机构:
Hacettepe Univ, Fac Med, Dept Psychiat, TR-06100 Ankara, Turkey
Univ Maastricht, Fac Hlth Med & Life Sci, Dept Neurosci, Maastricht, Netherlands
European Grad Sch Neurosci EURON, Maastricht, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Basar, Koray
;
Sesia, Thibaut
论文数: 0引用数: 0
h-index: 0
机构:
Maastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Univ Maastricht, Fac Hlth Med & Life Sci, Dept Neurosci, Maastricht, Netherlands
European Grad Sch Neurosci EURON, Maastricht, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Sesia, Thibaut
;
Groenewegen, Henk
论文数: 0引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam Med Ctr, Dept Anat & Neurosci, Amsterdam, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Groenewegen, Henk
;
Steinbusch, Harry W. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maastricht, Fac Hlth Med & Life Sci, Dept Neurosci, Maastricht, Netherlands
European Grad Sch Neurosci EURON, Maastricht, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Steinbusch, Harry W. M.
;
Visser-Vandewalle, Veerle
论文数: 0引用数: 0
h-index: 0
机构:
Maastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
European Grad Sch Neurosci EURON, Maastricht, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Visser-Vandewalle, Veerle
;
Temel, Yasin
论文数: 0引用数: 0
h-index: 0
机构:
Maastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands
Univ Maastricht, Fac Hlth Med & Life Sci, Dept Neurosci, Maastricht, Netherlands
European Grad Sch Neurosci EURON, Maastricht, NetherlandsMaastricht Univ Med Ctr, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands