Molecular interactions of the IGF system

被引：322

作者：

Denley, A

Cosgrove, LJ

Booker, GW

Wallace, JC

Forbes, BE ^{[1
]}

机构：

[1] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA 5005, Australia

[2] CSIRO, Div Hlth Sci & Nutr, Adelaide, SA, Australia

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2005年 / 16卷 / 4-5期

关键词：

insulin-like growth factor; IGF receptors; IGFBP; structure; function;

D O I：

10.1016/j.cytogfr.2005.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The insulin-like growth factor (IGF) system is a complex network of two soluble ligands; several cell surface transmembrane receptors and six soluble high-affinity binding-proteins. The IGF system is essential for normal embryonic and postnatal growth, and plays an important role in the function of a healthy immune system, lymphopoiesis, myogenesis and bone growth among other physiological functions. Deregulation of the IGF system leads to stimulation of cancer cell growth and survival. In order to manipulate the IGF system in the treatment of certain disorders, we must understand the protein-protein interactions at a molecular level. The complex molecular interactions of the ligands and receptors of the IGF system underlie all the biological actions mentioned above and will be the focus of this review. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：421 / 439

页数：19

共 124 条

[71]

KUROSE T, 1994, J BIOL CHEM, V269, P29190

[72]

LAAJOKI L, 1998, 4278 BIOMAGRESBANK

[73] Extensive personal experience - Laron syndrome (primary growth hormone resistance or insensitivity): The personal experience 1958-2003 [J].