Use of spin label EPR spectra to monitor peptide chain aggregation inside resin beads.

被引：51

作者：

Cilli, EM

Marchetto, R

Schreier, S

Nakaie, CR

机构：

[1] UNESP,INST CHEM,DEPT BIOCHEM,BR-14800060 ARARAQUARA,SP,BRAZIL

[2] UNIV SAO PAULO,INST CHEM,DEPT BIOCHEM,BR-05599970 SAO PAULO,BRAZIL

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/S0040-4039(96)02363-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An EPR approach to monitor peptide chain aggregation inside resin beads is introduced. Model low and highly peptide-loaded resins containing an aggregating sequence were labeled with a paramagnetic amino acid derivative and studied with regard to their solvation behavior in different solvent systems. For the first time in the peptide synthesis, EPR spectroscopic has allowed the detection of differentiated levels of peptide chain aggregation as a function of solvent and resin loading. (C) 1997, Elsevier Science Ltd. All rights reserved.

引用

页码：517 / 520

页数：4

共 19 条

[1]

[Anonymous], BIOL MAGNETIC RESONA

[2]

Atherton E., 1989, SOLID PHASE PEPTIDE

[3]

Barany G., 1980, PEPTIDES ANAL SYNTHE, V2, P1

[4]

CILLI EM, 1996, PEPTIDES CHEM STRUCT, P103