Effects of nicotinic stimulation on cognitive performance

被引:322
作者
Newhouse, PA [1 ]
Potter, A [1 ]
Singh, A [1 ]
机构
[1] Univ Vermont, Coll Med, Dept Psychiat, Clin Neurosci Res Unit, S Burlington, VT 05403 USA
关键词
D O I
10.1016/j.coph.2003.11.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recent advances in studies of nicotinic agents in humans have begun to more carefully define cognitive operations that can be influenced by nicotinic stimulation and/or blockade. Careful separation of the cognitive domains affected by nicotinic stimulation has identified attentional performance as the most likely candidate to be positively influenced by nicotinic receptor activation. Studies of the effects of nicotinic systems and/or nicotinic receptor stimulation in pathological disease states such as Alzheimer's disease, Parkinson's disease, attention deficit/hyperactivity disorder and schizophrenia show the potential for therapeutic utility of nicotinic drugs. In contrast to studies in pathological states, studies of nicotine in normal-non-smokers tend to show deleterious effects. This contradiction can be resolved by consideration of cognitive and biological baseline dependency differences between study populations in terms of the relationship of optimal cognitive performance to nicotinic receptor activity. Although normal individuals are unlikely to show cognitive benefits after nicotinic stimulation except under extreme task conditions, individuals with a variety of disease states can benefit from nicotinic drugs. Attentional function/dysfunction may serve as an endophenotypic therapeutic target for nicotinic drug development.
引用
收藏
页码:36 / 46
页数:11
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