Mucin dynamics and enteric pathogens

被引：1054

作者：

McGuckin, Michael A. ^{[1
,2
]}

Linden, Sara K. ^{[3
]}

Sutton, Philip ^{[4
]}

Florin, Timothy H. ^{[1
,2
]}

机构：

[1] Mater Med Res Inst, Immun Infect & Inflammat Program, Brisbane, Qld 4101, Australia

[2] Univ Queensland, Sch Med, Brisbane, Qld 4101, Australia

[3] Gothenburg Univ, Mucosal Immunobiol & Vaccine Ctr, S-40530 Gothenburg, Sweden

[4] Univ Melbourne, Sch Vet Sci, Ctr Anim Biotechnol, Parkville, Vic 3010, Australia

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 04期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

NECROSIS-FACTOR-ALPHA; NEMATODE NIPPOSTRONGYLUS-BRASILIENSIS; PANCREATIC-CANCER CELLS; HELICOBACTER-PYLORI; GENE-EXPRESSION; UP-REGULATION; GOBLET CELL; STIMULATES MUCIN; IN-VITRO; EPITHELIAL-CELLS;

D O I：

10.1038/nrmicro2538

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The extracellular secreted mucus and the cell surface glycocalyx prevent infection by the vast numbers of microorganisms that live in the healthy gut. Mucin glycoproteins are the major component of these barriers. In this Review, we describe the components of the secreted and cell surface mucosal barriers and the evidence that they form an effective barricade against potential pathogens. However, successful enteric pathogens have evolved strategies to circumvent these barriers. We discuss the interactions between enteric pathogens and mucins, and the mechanisms that these pathogens use to disrupt and avoid mucosal barriers. In addition, we describe dynamic alterations in the mucin barrier that are driven by host innate and adaptive immune responses to infection.

引用

页码：265 / 278

页数：14

共 185 条

[1] MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling [J].

Ahmad, Rehan ;

Raina, Deepak ;

Trivedi, Vishal ;

Ren, Jian ;

Rajabi, Hasan ;

Kharbanda, Surender ;

Kufe, Donald .

NATURE CELL BIOLOGY, 2007, 9 (12) :1419-U146

[2] TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation [J].

Ahn, DH ;

Crawley, SC ;

Hokari, R ;

Kato, S ;

Yang, SC ;

Li, JD ;

Kim, YS .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2005, 15 (1-4) :29-40

[3] Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA [J].

Amieva, MR ;

Vogelmann, R ;

Covacci, A ;

Tompkins, LS ;

Nelson, WJ ;

Falkow, S .

SCIENCE, 2003, 300 (5624) :1430-1434

[4] IFN-γ-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation:: a novel mechanism for IFN-γ response [J].

Andrianifahanana, M. ;

Singh, A. P. ;

Nemos, C. ;

Ponnusamy, M. P. ;

Moniaux, N. ;

Mehta, P. P. ;

Varshney, G. C. ;

Batra, S. K. .

ONCOGENE, 2007, 26 (51) :7251-7261

[5] Tumor necrosis factor α is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection [J].

Artis, D ;

Humphreys, NE ;

Bancroft, AJ ;

Rothwell, NJ ;

Potten, CS ;

Grencis, RK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (07) :953-962

[6] Characterization of two different endo-α-N-acetylgalactosaminidases from probiotic and pathogenic enterobacteria, Bifidobacterium longum and Clostridium perfringens [J].

Ashida, Hisashi ;

Maki, Riichi ;

Ozawa, Hayato ;

Tani, Yasushi ;

Kiyohara, Masashi ;

Fujita, Masaya ;

Imamura, Akihiro ;

Ishida, Hideharu ;

Kiso, Makoto ;

Yamamoto, Kenji .

GLYCOBIOLOGY, 2008, 18 (09) :727-734

[7] Functional adaptation of BabA, the H-pylori ABO blood group antigen binding adhesin [J].

Aspholm-Hurtig, M ;

Dailide, G ;

Lahmann, M ;

Kalia, A ;

Ilver, D ;

Roche, N ;

Vikström, S ;

Sjöström, R ;

Lindén, S ;

Bäckström, A ;

Lundberg, C ;

Arnqvist, A ;

Mahdavi, J ;

Nilsson, UJ ;

Velapatiño, B ;

Gilman, RH ;

Gerhard, M ;

Alarcon, T ;

López-Brea, M ;

Nakazawa, T ;

Fox, JG ;

Correa, P ;

Dominguez-Bello, MG ;

Perez-Perez, GI ;

Blaser, MJ ;

Normark, S ;

Carlstedt, I ;

Oscarson, S ;

Teneberg, S ;

Berg, DE ;

Borén, T .

SCIENCE, 2004, 305 (5683) :519-522

[8] The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo [J].

Atuma, C ;

Strugala, V ;

Allen, A ;

Holm, L .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 280 (05) :G922-G929

[9] Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa [J].

Bergstrom, Kirk S. B. ;

Kissoon-Singh, Vanessa ;

Gibson, Deanna L. ;

Ma, Caixia ;

Montero, Marinieve ;

Sham, Ho Pan ;

Ryz, Natasha ;

Huang, Tina ;

Velcich, Anna ;

Finlay, B. Brett ;

Chadee, Kris ;

Vallance, Bruce A. .

PLOS PATHOGENS, 2010, 6 (05)

[10] Commensal ocular bacteria degrade mucins [J].

Berry, M ;

Harris, A ;

Lumb, R ;

Powell, K .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2002, 86 (12) :1412-1416

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